+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Scintigraphic evaluation of enterogastric reflux using 75Se-HCAT: methodology and first clinical observations



Scintigraphic evaluation of enterogastric reflux using 75Se-HCAT: methodology and first clinical observations



European Journal of Nuclear Medicine 13(5): 230-233



The aim of this study was to assess the possibility of detecting enterogastric reflux (EGR) by 75Se-HCAT cholescintigraphy. The lowest detectable activity in the gastric area at different concentrations of the radiotracer in the gallbladder was preliminary measured both in a plastic phantom and in an in vivo model. Ten patients were studied after a single oral administration of 1480 KBq 75Se-HCAT. Gamma camera imaging was carried out for five consecutive days during both fasting and after meal ingestion. In our in vivo model an EGR corresponding to 1% of gallbladder content on day one and 8% on day five was detected. In three out of five patients in whom bile was present in the stomach at endoscopy, 75Se-HCAT cholescintigraphy demonstrated an EGR, while in three out of five patients in whom endoscopy was negative, 75Se-HCAT cholescintigraphy detected EGR either during fasting or after meal ingestion. As EGR is not constant, 75Se-HCAT may be a useful tracer of bile to detect EGR over a prolonged period of time and in different physiological conditions.

(PDF emailed within 1 workday: $29.90)

Accession: 041310075

Download citation: RISBibTeXText

PMID: 3665969


Related references

Scintigraphic evaluation of enterogastric reflux using75Se-HCAT: Methodology and first clinical observations. European Journal of Nuclear Medicine and Molecular Imaging 13(5): 230-233, 1987

Measurement of bile acid half-life using [75Se]HCAT in health and intestinal diseases. Comparison with [75Se]HCAT abdominal retention methods. Digestive Diseases and Sciences 37(2): 225-232, 1992

The Migrating Motor Complex and the Enterohepatic Circulation of Bile Acids: A Scintigraphic Study Using 75Se-HCAT. Neurogastroenterology & Motility 3(1): 1-4, 1991

Tests for the absorption of 75Se-labelled homocholic acid conjugated with taurine (75Se-HCAT). European Journal of Nuclear Medicine 10(9-10): 455-457, 1985

Estimation of the enterogastric reflux by modified scintigraphic method. Hepato-Gastroenterology 47(33): 738-741, 2000

New scintigraphic method for the quantitative measurement of enterogastric reflux. Scandinavian Journal of Gastroenterology 19(7): 947-952, 1984

Enterogastric reflux in normal subjects and patients with Bilroth II gastroenterostomy. Measurement of enterogastric reflux. Gastroenterology 77(5): 1027-1033, 1979

Comparative studies of various methods of measuring bile acid secretion using 75Se-labelled homotaurocholic acid (75Se-HCAT). Nuklearmedizin. Nuclear Medicine 22(5): 258-261, 1983

Gastroesophageal reflux in asthmatic children not responding to asthma medication: a scintigraphic study in 126 patients with correlation between scintigraphic and clinical findings of reflux. Clinical Imaging 27(5): 333-336, 2003

Enterogastric reflux: experimental and clinical aspects. Acta Chirurgica Belgica 87(5): 313-316, 1987

Scintigraphic evaluation of the pancreatic function from intestinal 75Se radioactivity. Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 111(3): 420-426, 1969

Evaluation of enterogastric reflux using a modified scintigraphy method. Acta Chirurgica Iugoslavica 44-45(1-1): 31-35, 1997

The human cationic amino acid transporters hCAT-1, hCAT-2A and hCat-2B Three related carriers with distinct transport properties. Amino Acids 13(1): 47-48, 1997

Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties. Biochemistry 36(21): 6462-6468, 1997

Evaluation of enterogastric reflux in relation to functional status of the gallbladder. Acta Chirurgica Iugoslavica 48(3): 49-53, 2002