Semisynthetic beta-lactam antibiotics. II. Synthesis and antibacterial activity of 7beta-[2- (acylamino) -2- (2-aminothiazol-4-yl) acetamido]cephalosporins
Arimoto, M.; Ejima, A.; Watanabe, T.; Tagawa, H.; Furukawa, M.
Journal of Antibiotics 39(9): 1236-1242
1986
ISSN/ISBN: 0021-8820 PMID: 3781922 DOI: 10.7164/antibiotics.39.1236
Accession: 041328854
Cephalosporin derivatives (I) substituted with a neutral, acidic or basic amino acid group as the terminal group attached to the 2-amino-2-(2-aminothiazol-4-yl)acetamido side chain at the C-7 position were synthesized, and the effect of each group on antibacterial activity was examined. The derivatives bearing an amidino or guanidino group showed broad spectra of antibacterial activity similar to those of cefotaxime, but they were relatively sensitive to beta-lactamases.
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