Serum activity of lysosomal enzymes in relationship to contraceptive steroid dose

Briggs, M.H.; Briggs, M.

Current Medical Research and Opinion 3(4): 203-205


ISSN/ISBN: 0300-7995
PMID: 1149488
DOI: 10.1185/03007997509113672
Accession: 041342239

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Women using combined-type oral contraceptives show a progressive increase in serum activity of lysosomal enzymes (beta-glucuronidase and beta-acetyl-glucuronidase) during the first 6 cycles of treatment; thereafter, the enzyme activities remain relatively constant. The increase in enzyme activity appears to be approximately proportional to the total steroid intake per cycle and not to any particular steroid or combination of steroids. These findings suggest that oral contraceptives of choice should contain the minimum amount of steroids compatible with high efficacy and patient acceptability.