+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Serum insulin-like growth factors and insulin-like growth factor binding proteins in the human fetus. Relationships with growth in normal subjects and in subjects with intrauterine growth retardation



Serum insulin-like growth factors and insulin-like growth factor binding proteins in the human fetus. Relationships with growth in normal subjects and in subjects with intrauterine growth retardation



Pediatric Research 29(3): 219-225



IGF-I, IGF-II, and their binding proteins (BP) were studied in sera obtained by direct puncture of umbilical cords in utero between 20 and 37 wk of gestation in 103 normal fetuses and in 16 fetuses with intrauterine growth retardation, as well as in the cord blood of 37 normal newborns of 38- to 42-wk pregnancies. In normal fetuses, IGF-I levels were approximately 50 ng/mL and IGF-II levels approximately 350 ng/mL up to the 33rd wk of pregnancy. Thereafter, both increased to reach values two to three times higher at term. Correlations were found between fetal placental lactogen levels and those of IGF-I and IGF-II, which is consistent with the hypothesis that placental lactogen is involved in the regulation of IGF synthesis in the fetus. With weight (either measured at birth or deduced from echographical data) as index of fetal size, IGF-I levels were significantly (p less than 0.001) higher in fetuses with weights above the mean for gestational age than in fetuses with weights below the mean, whereas IGF-II levels were similar in the two groups. Similarly, IGF-I (but not IGF-II) levels in fetuses with intrauterine growth retardation were significantly lower than those in normal fetuses of the same age (p less than 0.01). These findings suggest that, during the latter months of intrauterine life, IGF-I (but not IGF-II) is involved in the control of fetal size. Total fetal BP concentrations were approximately 1/3 those of adults. The fetal electrophoretic profile obtained by Western-ligand blotting bore a strong resemblance to that of subjects with growth hormone deficiency.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 041345197

Download citation: RISBibTeXText

PMID: 1709729

DOI: 10.1203/00006450-199103000-00001


Related references

Growth factors and intrauterine growth retardation. II. Serum growth hormone, insulin-like growth factor (IGF) I, and IGF-binding protein 3 levels in children with intrauterine growth retardation compared with normal control subjects: prospective study from birth to two years of age. Study Group of IUGR. Pediatric Research 40(1): 101-107, 1996

Growth factors and intrauterine growth retardation. I. Serum growth hormone, insulin-like growth factor (IGF)-I, IGF-II, and IGF binding protein 3 levels in normally grown and growth-retarded human fetuses during the second half of gestation. Pediatric Research 40(1): 94-100, 1996

Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth. Journal of Clinical Endocrinology and Metabolism 80(5): 1548-1555, 1995

Effects of L-arginine on the expression of insulin-like growth factors and insulin-like growth factor binding protein 3 in rats with intrauterine growth retardation. Zhongguo Dang Dai Er Ke Za Zhi 8(4): 319-322, 2006

Maternal and fetal serum insulin-like growth factor-1, insulin-like growth factor binding protein-3, leptin levels in intrauterine growth retardation. Hormone Research 51(SUPPL 2): 27, 1999

Evidence for production by the liver of 2 insulin like growth factor binding proteins with similar molecular weights but different affinities for insulin like growth factor i and insulin like growth factor ii their relations with serum and cerebro spinal fluid insulin like growth factor binding proteins. Journal of Clinical Endocrinology & Metabolism 55(3): 600-602, 1982

Insulin-like growth factors I and II, and insulin-like growth factor-binding proteins -1 and -3 in intrauterine growth-retarded newborns Relationship to auxological parameters. Acta Paediatrica Suppl. (423): 141, 1997

Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye disease. Studies in nondiabetic and diabetic subjects. Journal of Clinical Investigation 92(6): 2620-2625, 1993

Growth hormone, insulin-like growth factor I and its binding proteins 1 and 3 in last trimester intrauterine growth retardation with increased pulsatility index in the umbilical artery. Clinical Endocrinology. 45(3): 315-319, 1996

Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction. Journal of Perinatal Medicine 39(6): 701-707, 2012

Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic human immunodeficiency virus-infected patients. Metabolism: Clinical and Experimental 53(12): 1565-1573, 2004

Umbilical cord serum levels of insulin-like growth factor-1, insulin and growth hormone in neonates with intrauterine growth retardation. Zhongguo Dang Dai Er Ke Za Zhi 12(10): 771-773, 2010

Effects of maternal protein malnutrition on fetal growth, plasma insulin-like growth factors, insulin-like growth factor binding proteins, and liver insulin-like growth factor gene expression in the rat. Pediatric Research 37(3): 334-342, 1995

Expression of serum insulin-like growth factors, insulin-like growth factor-binding proteins, and the growth hormone-binding protein in heterozygote relatives of Ecuadorian growth hormone receptor deficient patients. Journal of Clinical Endocrinology and Metabolism 74(4): 743-750, 1992

Insulin resistance and insulin-like growth factors in children with intrauterine growth retardation. Is catch-up growth a risk factor?. Hormone Research 55 Suppl 1: 7-10, 2001