+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Significance of IgM antibody to hepatitis B core antigen for the differential diagnosis of acute and chronic hepatitis B virus infection and for the evaluation of the inflammatory activity of type B chronic liver diseases



Significance of IgM antibody to hepatitis B core antigen for the differential diagnosis of acute and chronic hepatitis B virus infection and for the evaluation of the inflammatory activity of type B chronic liver diseases



Gastroenterologia Japonica 21(6): 601-607



IgM antibody to hepatitis B core antigen (anti-HBc) was assayed using a commercial kit in acute and chronic hepatitis B virus (HBV) infection and evaluated for its diagnostic and clinical significance. IgM anti-HBc was positive in all of 21 cases with type B acute hepatitis in the acute phase, and was also detected in 5 of 20 cases with type B chronic persistent hepatitis, in 4 of 20 patients with type B chronic active hepatitis and in one of 10 with type B liver cirrhosis. The absence of this marker was noted in all of 20 asymptomatic hepatitis B surface antigen (HBsAg) carriers and in 50 with HBsAg-negative patients with liver disease and in 200 healthy blood donors. The cut-off index of IgM anti-HBc was greater than 2.0 in all serum samples obtained in the acute phase of type B acute hepatitis, but was below 2.0 in type B chronic liver disease. A close relationship was found between the presence of IgM anti-HBc and the degree of inflammatory activity in patients with HBsAg-positive chronic liver disease. These data show that examination of IgM anti-HBc is useful in distingushing type B acute hepatitis from type B chronic liver disease, and also in evaluating the severity of disease in type B chronic liver disease.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 041362652

Download citation: RISBibTeXText

PMID: 3569748

DOI: 10.1007/bf02774488


Related references

Age specific prevalence and significance of hepatitis b e antigen and antibody in chronic hepatitis b virus infection in taiwan a comparison among asymptomatic carriers chronic hepatitis liver cirrhosis and hepato cellular carcinoma. Journal of Medical Virology 13(4): 385-392, 1984

Correlation of the e antigen antibody system with intra hepato cellular hepatitis b core antigen and hepatitis b surface antigen in hepatitis b surface antigen positive acute and chronic liver diseases and healthy hepatitis b surface antigen carriers. Digestion 14(5/6): 488, 1976

Significance of IgM antibody to hepatitis B core antigen in a Greek population with chronic hepatitis B virus infection. Liver 6(5): 275-280, 1986

Clinical significance of low or negative titer of antibody to hepatitis B core antigen during the course of chronic hepatitis B virus infection in adolescents. Gastroenterologia Japonica. 28(1): 25-33, 1993

The target antigen of liver kidney microsomal antibody is different in type ii autoimmune chronic active hepatitis and chronic hepatitis c virus infection. Journal of Hepatology 16(Suppl. 1): S4, 1992

The significance of demonstrating anti hepatitis b core antigen of the immuno globulin m class for the diagnosis of acute and chronic hepatitis b infection. Zentralblatt fuer Bakteriologie 1 Abt Originale A Medizinische Mikrobiologie Infektionskrankheiten und Parasitologie 246(4): 462, 1980

Immunoglobulin m antibody to hepatitis b core antigen in asymptomatic hepatitis b surface antigen carriers and hepatitis b virus associated chronic liver disease. Journal of Hepatology (Suppl. 1): S147, 1985

Immunoglobulin A antibody against hepatitis B core antigen of polymeric and monomeric forms, as well as of IgA1 and IgA2 subclasses, in acute and chronic infection with hepatitis B virus. Hepatology 6(4): 652-657, 1986

Detection of hepatitis b core antigen without hepatitis b surface antigen in the liver or anti hepatitis b core antigen antibody alone in the serum as a reflection of infection by a hepatitis b related non a non b virus. Hepatology 2(5): 686, 1982

Clinical significance of immunoglobulin A antibody to hepatitis B core antigen of polymeric and monomeric forms in chronic type B liver disease with acute exacerbation. American Journal of Gastroenterology 83(12): 1390-1394, 1988

Association Between High Levels of Hepatitis B Core Antibody and Seroclearance of Hepatitis B e Antigen in Individuals With Chronic Hepatitis B Virus Infection. Clinical Gastroenterology and Hepatology 17(7): 1413-1415, 2019

Antibody to hepatitis B core antigen as a screening test for occult hepatitis B virus infection in Egyptian chronic hepatitis C patients. Journal of Gastroenterology 44(4): 359-364, 2009

Significance of hepatitis B core antigen in the liver in patients with chronic hepatitis B and its relation to hepatitis B virus DNA. Journal of Gastroenterology and Hepatology 5(3): 239-243, 1990

A radio immunoassay for hepatitis b core antigen in the sera of hepatitis b surface antigen carriers serum hepatitis b core antigen serum dna polymerase activity and liver hepatitis b core antigen immuno fluorescence as markers of chronic liver disease. Gastroenterology 80(6): 1420-1427, 1981

IgM antibody to a hepatitis C virus core peptide (CP14) for monitoring activity of liver disease in patients with acute or chronic hepatitis C. Journal of Medical Virology 42(3): 311-317, 1994