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Some effects of mianserin on monoamine metabolism in the rat brain

Some effects of mianserin on monoamine metabolism in the rat brain

British Journal of Clinical Pharmacology 5(Suppl. 1): 11s-12s

1 Mianserin does not affect the uptake of biogenic amines into rat brain, in contrast to tricyclic antidepressants which block amine uptake. 2 Mianserin increases the turnover of noradrenaline (NA) in rat brain after acute or chronic administration, whereas tricyclic antidepressants reduce turnover of NA and 5-hydroxytryptamine. 3 It should not be assumed that a compound must inhibit amine re-uptake mechanisms before it can be considered as a potential antidepressant.

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Accession: 041395789

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PMID: 623700

DOI: 10.1111/j.1365-2125.1978.tb04568.x

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