Section 42
Chapter 41,407

Specific interactions between transcription factors and the promoter-regulatory region of the human cytomegalovirus major immediate-early gene

Ghazal, P.; Lubon, H.; Hennighausen, L.

Journal of Virology 62(3): 1076-1079


ISSN/ISBN: 0022-538X
PMID: 2828657
Accession: 041406733

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Repeat sequence motifs as well as unique sequences between nucleotides -150 and -22 of the human cytomegalovirus immediate-early 1 gene interact in vitro with nuclear proteins. We show that a transcriptional element between nucleotides -91 and -65 stimulated promoter activity in vivo and in vitro by binding specific cellular transcription factors. Finally, a common sequence motif, (T)TGG/AC, present in 15 of the determined binding sites suggests a particular class of nuclear factors associated with the immediate-early 1 gene.

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