+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Specificity of the binding of trifluoperazine to the calcium-dependent activator of phosphodiesterase and to a series of other calcium-binding proteins

, : Specificity of the binding of trifluoperazine to the calcium-dependent activator of phosphodiesterase and to a series of other calcium-binding proteins. Biochimica et Biophysica Acta 540(2): 197-204

Trifluoperazine inhibits the activation of phosphodiesterase by binding to the calcium-dependent activator. To determine further the specificity by which trifluoperazine binds to activator, we compared the binding of trifluoperazine to activator prepared from several species and tissues and to a number of other calcium-binding proteins devoid of activator activity. Trifluoperazine binds to activator prepared from human, bovine, rat and rabbit brain and from chick embryo fibroblasts. In each case, the binding of trifluoperazine to activator was qualitatively similar and related quantitatively to the ability of the preparation to activate phosphodiesterase. Of the other calcium-binding proteins examined, namely, troponin-C, S-100 protein, phospholipase A, phospholipase B and myosin light chain, only troponin-C displayed any significant calcium-specific binding of trifluoperazine. The binding to troponin-C, however, appeared to be different from the binding to activator; whereas the binding of trifluoperazine to actovator showed no cooperativity, the binding to troponin-C showed positive cooperatively. These results and earlier data showing that trifluoperazine fails to bind to a variety of other proteins, indicate that the binding of trifluoperazine to the calcium-dependent activator of phosphodiesterase is selective and suggest that this binding may explain some of the biochemical and pharmacological actions of this antipsychotic agent.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 041408279

PMID: 207350

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Thomas R. H.; Thompson D. E.; Bindschadler R. A.; MacAyeal D. R., 1983: Ice-sheet melting and sea level. Proceedings of the Symposium on Coastal and Ocean Management 3: 2846-2857

Jackson J. M.; Zhang J.; Bass J. D., 2004: Sound velocities of aluminous perovskite and ferropericlase at high-pressure; implications for Earth's deep interior. Eos, Transactions, American Geophysical Union 85(47, Suppl

Bernardini-Zambrini, D.A., 2012: Healthy aging and intergenerational solidarity - Latin America and its moment of opportunity. Colombia Medica 43(2): 112-113

Lafreniere,M.; Lamoureux,S., 2008: Seasonal dynamics of dissolved nitrogen exports from two High Arctic watersheds, Melville Island, Canada. This study examines the magnitude and seasonal patterns of dissolved N export during the 2006 melt season from two small watersheds on Melville Island, in the Canadian High Arctic. The dominant N species was dissolved organic nitrogen (DON), compr...

Dagallier Guy, 1993: Lead-baritic arkoses of the High Moulouya Triassic, Morocco; trapping and intrapedimentary concentrations. Mines, Geologie et Energie 54: 83-99

Drury P.J.; Bodnar E.; Ross D.N., 1979: Energy transfer and energy distribution during intra aortic balloon pumping. Artificial Organs 3(3): 295

Ventura M.M.; Ikemoto H.; Muzuta K., 1982: Fluorescence of black eyed pea trypsin and chymotrypsin inhibitor modified with pyridoxal 5 phosphate. A conjugate containing 1 mol of pyridoxal-5'-phosphate/mol of black-eyed pea trypsin and chymotrypsin inhibitor (BTCI) was obtained by reacting ligand and protein at a molar ratio of 1:1. The inhibitory activities against .beta.-trypsin (bovi...

GUSEL'NIKOVA, M.I., 1960: Modifications in biological properties of staphylococci isolated from patients with staphyloderma before and after penicillin therapy. Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta 51(): 226-230

Lind G.A.M., 1979: Auto traction in the treatment of chronic low back pain and sciatica effect on neurological symptoms. Acta Orthopaedica Scandinavica: 110

Vovou, I.; Delitheos, A.; Tiligada, E., 2004: The heat shock response is dependent on the external environment and on rapid ionic balancing by pharmacological agents in Saccharomyces cerevisiae. Journal of Applied Microbiology 96(6): 1271-1277