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Specificity of the digoxin radioimmunoassay with respect to dihydrodigoxin

, : Specificity of the digoxin radioimmunoassay with respect to dihydrodigoxin. Research Communications in Chemical Pathology and Pharmacology 14(1): 83-88

An investigation was conducted to determine the specificity of the digoxin antibody provided in a commercially available radioimmunoassay kit with respect to dihydrodigoxin. Over the concentration range of 0.5 to 8.0 ng./ml. dihydrodigoxin displaced the 125I digoxin derivative from the antibody to a degree that could be significant at clinically observed serum and urine digoxin concentrations.

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Accession: 041408296

PMID: 935656

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Related references

Butler, V.P.; Tse-Eng, D.; Lindenbraum, J.; Kalman, S.M.; Preibisz, J.J.; Rund, D.G.; Wissel, P.S., 1982: The development and application of a radioimmunoassay for dihydrodigoxin, a digoxin metabolite. The cardioinactive digoxin metabolite, dihydrodigoxin, has been conjugated to bovine serum albumin and to bovine pancreatic ribonuclease by the periodate oxidation method. Rabbits immunized with the dihydrodigoxin-bovine serum albumin conjugate fo...

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