+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Specificity, schedule, and proliferation dependence of infused L-histidinol after 5-fluorouracil in mice

, : Specificity, schedule, and proliferation dependence of infused L-histidinol after 5-fluorouracil in mice. Cancer Research 48(6): 1470-1475

L-Histidinol, an analogue of the amino acid L-histidine, has been reported to be able to increase the specificity of 5-fluorouracil (FUra), through both protection of normal tissues at risk and potentiation of leukemic cell killing. It is postulated that this occurs through prevention of the entry of normal cells into the cell cycle through protein deficiency, while allowing malignant cells, permissive for protein starvation, to continue to cycle, thus maintaining sensitivity for cycle specific anticancer agents. Reported in this paper is the confirmation of these L-histidinol-FUra effects. However, a modification was made by which more L-histidinol could be given and more consistent protection of whole animals demonstrated. Further, an optimal schedule of L-histidinol was defined in which FUra preceded L-histidinol infusion. Finally, the specificity and proliferation dependence of this schedule was evaluated on colony forming units-spleen in resting and proliferating state, colony forming units-granulocyte-macrophage, and L1210 leukemia. This demonstrates that the FUra/L-histidinol combination indeed protects only normal cells but that the postulated proliferation dependence is absent, indicating an alternate biological mechanism.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 041408427

PMID: 3345520

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Zakharyan K.A., 1967: The fauna of ancient armenia on the basis of archaeological data. Sbornik Nauchnykh Trudov Armyanskogo Gosudarstvennogo Zaochnogo Pedagogicheskogo Instituta (6(T 2): 121-152

Suitanov, Rl, 1985: Quality of queen honeybees in relation to their weight. Pchelovodstvo (7) 10

COSMOS, E., 1964: Intracellular Distribution Of Calcium In Developing Breast Muscle Of Normal And Dystrophic Chickens. To follow the intracellular distribution of calcium in the breast muscles of developing chickens, Ca(45) was injected into the albumen of predeveloped eggs. Since the embryos were grown in a radioactive medium, a complete exchange of the isotope f...

Sihag R.K.; Nixon R.A., 1987: Identification of protein kinases involved in the phosphorylation of 70k subunit of mammalian neurofilament proteins in vivo and in vitro. Journal of Neurochemistry 48(SUPPL): S101

Dean D.J.; Weintraub B.D.; Rosen S.W., 1980: De novo synthesis and secretion of heterogeneous forms of human chorionic gonadotropin and its free alpha subunit in the human chorio carcinoma clonal cell line jeg 3. Cells at near confluence were labeled with [35S]Met by continuous (10-min to 24-h exposure) and by pulse-chase (5-min exposure, 10-min to 4-h chase) techniques. Media and cell lysates, chromatographed on Sephadex G-100 or, after reduction, electro...

Chase, M. E.; Bailey, R. C., 1996: Recruitment of Dreissena polymorpha: Does the presence and density of conspecifics determine the recruitment density and pattern in a population?. Results of a field experiment conducted to examine the density and spatial pattern of recruitment in a population of Dreissena polymorpha in Lake St. Clair were consistent with the hypothesis that recruitment is in response to a chemical cue relea...

Kazanskiy V. I.; Kuznetsov O. L.; Kuznetsov A. V.; Lobanov K. V.; Cheremisina Ye N., 1994: Deep-seated structures and geodynamics of Pechenga ore region; experience from investigation of the Kola superdeep well. Geologiya Rudnykh Mestorozhdeniy 36(6): 500-519

Kondo, N.; Murakami, Y.; Uemura, K.; Sudo, T.; Hashimoto, Y.; Nakashima, A.; Sueda, T., 2013: Combined analysis of dihydropyrimidine dehydrogenase and human equilibrative nucleoside transporter 1 expression predicts survival of pancreatic carcinoma patients treated with adjuvant gemcitabine plus S-1 chemotherapy after surgical resection. Although postoperative adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PDAC) improves survival in some patients, the effectiveness varies by individual, and the results remain unsatisfying. The aim of this study was to investigate whet...

Dix, Me; Brandle, Jr; Bratton, Gf; Wardle, Td, 1990: Potential effects of climate change on tree survival and forest pests in the Great Plains. Proceedings of the Society of American Foresters National Convention: 71-175

Abstracts., 1984: Meeting of the American Association of Vetrinary Anatomists Department of Anatomy, Cornell University New York State College of Veterinary Medicine Ithaca, New York Juli 16-17, 1983. Zentralblatt fuer Veterinaermedizin Reihe C: 133: 261-281