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Spectral properties of nonequilibrium states in cytochrome P-450 formed by reduction at subzero temperatures

, : Spectral properties of nonequilibrium states in cytochrome P-450 formed by reduction at subzero temperatures. Acta Biologica et Medica Germanica 38(2-3): 443-448

Nonequilibrium conformational states in cytochrome P-450 in the presence and absence of substrates formed by reduction at subzero temperatures with hydrates electrons were obtained and characterized by their absorption spectra. Different absorption spectra between the relaxed (298 K) and the non-relaxed enzyme forms (77 K) indicate conformational changes proceeding in the relaxed form after reduction of the heme iron which lead to altered interactions between the active centre and its environment in the protein. The two maxima of the nonequilibrium form of cytochrome P-450 without substrate in the visible absorption spectrum (alpha-band, beta-band) and the ratio of their intensities indicate the low-spin character of the heme iron. These spectral properties give evidence for a reduced cytochrome P-450 with two heme-linked axial ligands.

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Accession: 041408895

PMID: 517010

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