EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Steroidogenic and pressor activity of angiotensin analogues in the rat


Steroidogenic and pressor activity of angiotensin analogues in the rat



Clinical Science and Molecular Medicine. Supplement 4: 175s-177s



ISSN/ISBN: 0144-4107

PMID: 282047

DOI: 10.1042/cs055175s

1. A classical 6 point assay in vitro for measuring aldosterone stimulating activity has been developed. 2. The steroidogenic potency of Ile5-angiotensin II was 62% of that given by Val5-angiotensin II. Ile5-angiotensin III (Des-Asp1-Ile5-angiotensin II) was likewise 50% as active as Val5-angiotensin III (Des-Asp1-Val5-angiotensin II). Similar results were obtained in the pressor and myotropic assays. 3. Ile5-angiotensin III and Val5-angiotensin III had only 7% and 16% respectively of the steroidogenic activity of Val5-angiotensin II. 4. Sar1-Ile5-angiotensin II was 2.3 times as potent as Val5-angiotensin II in aldosterone-stimulating activity. The corresponding activities of Me2-Gly1-angiotensin II, Pro1-angiotensin II and Pro31-angiotensin II were 71%, 15% and 3% of Val5-angiotensin II respectively.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 041434608

Download citation: RISBibTeXText

Related references

Action of (1-des(aspartic acid), 8-isoleucine) angiotensin II upon the pressor and steroidogenic activity of angiotensin II. Journal of Clinical Endocrinology and Metabolism 40(3): 530-533, 1975

Steroidogenic and pressor response to angiotensin ii and angiotensin iii in androgen treated dogs. Physiologist 27(4): 206, 1984

Effect of dietary potassium on the pressor and steroidogenic effects of angiotensin ii and angiotensin iii. Federation Proceedings 37(3): 811, 1978

Pressor and steroidogenic actions of deaspartyl 1 angiotensin i dependency on conversion to angiotensin iii. Circulation Research Suppl 40(1): I-94-I-97, 1977

Effect of sodium depletion on the steroidogenic and pressor actions of angiotensin in the rat. Clinical Science 56(4): 325-333, 1979

Des aspartic acid angiotensin i its steroidogenic and pressor effects in the conscious rat. Federation Proceedings 35(3): 704, 1976

Effects of verapamil upon the pressor and steroidogenic actions of angiotensin and acth. American Heart Association Monograph (91): II-64, 1982

The pressor response to exogenous angiotensin I and its blockade by angiotensin II analogues in the American alligator. General and Comparative Endocrinology 87(1): 141-148, 1992

(Des-Asp1) angiotensin I: a study of its pressor and steroidogenic activities in conscious rats. Endocrinology 100(1): 46-51, 1977

Actions of D-amino acid-substituted analogues of des-Asp-angiotensin I on the central pressor action of angiotensin III. European Journal of Pharmacology 294(1): 337-339, 1995

Alkylating angiotensin II analogues: synthesis, analysis, and biological activity of angiotensin II analogues containing the nitrogen mustard melphalan in position 8. Journal of Medicinal Chemistry 24(11): 1304-1310, 1981

The pressor and myotropic effects and the antagonistic properties of several analogues of angiotensin II. Canadian Journal of Physiology and Pharmacology 50(2): 99-112, 1972

The half-life of angiotensin II analogues in the rat, determined from the decay of the pressor response. Journal of Physiology 265(1): 35P-36P, 1977

Different angiotensin ii receptors mediate the pressor response to angiotensin ii and the pressor hyperresponse to norepinephrine in renal prehypertensive rabbits. Federation Proceedings 45(4): 896, 1986

The relationship of structure to pressor and oxytocic actions of isoleucine5 angiotensin octapeptide and various analogues. Biochim Et Biophys Acta 46(1): 38-44, 1961