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Studies of experimental cervical spinal cord transection. Part I: Hemodynamic changes after acute cervical spinal cord transection



Studies of experimental cervical spinal cord transection. Part I: Hemodynamic changes after acute cervical spinal cord transection



Journal of Neurosurgery 49(4): 558-562



Two distinct and sequential patterns of hemodynamic alteration were observed after acute cervical spinal cord transection in anesthetized dogs. Interruption of the cord initially caused a 45% increase in mean arterial pressure (P < 0.01), a 34% increase in systemic vascular resistance (P < 0.05) and a 92% increase in left ventricular dp/dt (maximum rate of fall in left ventricle pressure) (P < 0.01), reflecting a generalized sympathetic response to trauma. Concomitant bradycardia and escape arrhythmias suggested relative parasympathetic hyperactivity. Resolution of the brief pressor response was followed by a 2nd, more prolonged period characterized by a fall in arterial pressure to 71% of control levels (P < 0.05), a 16% decrease in systemic vascular resistance and a 58.5% decrease in left ventricular dp/dt (P < 0.01). These latter hemodynamic changes were consistant with sympathetic denervation and failure of regulatory mechanisms mediated by both .alpha.- and .beta.-adrenergic peripheral vascular and myocardial receptors.

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Accession: 041455396

Download citation: RISBibTeXText

PMID: 690685

DOI: 10.3171/jns.1978.49.4.0558


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