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Studies of the mechanism of desensitization of anti-IgE-mediated histamine release from human basophils



Studies of the mechanism of desensitization of anti-IgE-mediated histamine release from human basophils



Agents and Actions 27(1-2): 25-28



Human basophils became hyporesponsive to anti-IgE when exposed to this agent in the absence of Ca2+ for more than 10 min. The desensitization process proceeded in parallel to the releasing-process. The mechanism of desensitization seems to involve a very early step in the release-reaction, since the response to phospholipase A2 and diolein, agents involved in the release-reaction, was not affected by the desensitization.

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Accession: 041456836

Download citation: RISBibTeXText

PMID: 2473625

DOI: 10.1007/bf02222188


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