+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Studies on DNA content in ploidy patterns of esophageal cancer



Studies on DNA content in ploidy patterns of esophageal cancer



Nihon Geka Gakkai Zasshi 91(5): 564-574



The present study was undertaken to evaluate the nuclear DNA content of esophageal cancer cells consequent on the process of growth and progression of the cancer. In experimental animal studies, 47 esophageal cancers were induced in male Wistar rats by oral administration of N-amyl-N-methylnitrosamine (AMN) and were analysed in the study of ploidy patterns. The study was also carried out to determine the DNA content in the ploidy patterns in man. Primary tumors associated 421 metastatic lymph nodes in the 62 patients with thoracic esophageal cancer were subjected for the study of ploidy patterns. The nuclear DNA content was determined by means of flow cytometry. In the study of the experimentally-induced esophageal cancer in rats, aneuploidy was found in 18% at a depth of submucosa, 30% at proprial muscle, 59% at adventitia, and in 50% at a depth of neighboring structures, respectively. Clinically in man, the incidence of DNA diploidy and aneuploidy in the 62 primary cancers was 56% and 44%, respectively. In the 421 metastatic lymph nodes, diploid was found in 73% and aneuploid in 11%, while the combination of diploid and aneuploid was observed in 16%. Difference in the DNA index (DI) between the primary cancers and metastatic lymph nodes was found in 29 cases (46.8%), and the difference increased with progression of the cancer. Two hundred and ninety seven metastatic lymph nodes of 29 cases were subdivided into 4 groups based on the extent of the cancerous nests, and the DI value was found to be increased in proportion to the extension. With the results, the DI value of esophageal cancer appeared to be changed dependently by the variation of cell populations in the cancer or in the DNA content of the cancer cells.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 041457468

Download citation: RISBibTeXText

PMID: 2385220


Related references

P53 and ploidy studies in early esophageal cancer. Modern Pathology 7(1): 68A, 1994

Nuclear dna content in breast cancer relation between ploidy patterns and lymph node metastasis. Journal of Japan Society for Cancer Therapy 21(1): 103-107, 1986

Correlation between DNA ploidy patterns and tumor progression, prognosis, and tumor infiltrating lymphocytes in human esophageal cancer. Nihon Geka Gakkai Zasshi 91(11): 1659-1666, 1990

Ploidy patterns of megakaryocytes in patients with metastatic tumors and patients with limited cancer in comparison to control study groups a direct correlation between tumor volume and megakaryocyte dna content. Blut: 207, 1986

Role of DNA ploidy patterns in esophageal squamous cell carcinoma: An ultraviolet microspectrophotometric study. Cancer 74(2): 578-585, 1994

Studies on immunogenicity of esophageal cancer (the interaction between extracts of esophageal cancer and sera from esophageal cancer patients). Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae 2(2): 103-106, 1980

Histochemical studies on esophageal cancer. Comparison with experimental esophageal cancer in rats and esophageal cancer in humans. Igaku Kenkyu. Acta Medica 54(2): 203-220, 1984

Experimental and clinical studies on the esophageal stripping without thoracotomy of the esophageal cancer 3. application of transhiatal esophageal stripping for the aged with midthoracic im esophageal cancer. Iryo 45(5): 461-467, 1991

Analysis of p53 expression and DNA ploidy pattern in esophageal cancer. Gan to Kagaku Ryoho. Cancer and ChemoTherapy 22 Suppl 2: 110-114, 1995

Hyperthermo-radiosensitivity of esophageal cancer cells with high DNA ploidy in vitro. European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes 24(3): 180-187, 1992

Patterns of endo poly ploidy and 2c nuclear dna content feulgen in scilla decidua liliaceae. Plant Systematics & Evolution 131(3-4): 261-276, 1979

Prognostic value of dna ploidy and clinicopathologic parameters in esophageal cancer a flow cytometric analysis in 126 patients. Gastroenterology 98(5 PART 2): A304, 1990

An analysis of the DNA ploidy patterns of gastric cancer. Cancer 62(7): 1325-1330, 1988

DNA ploidy patterns in lung cancer and their prognostic value. Virchows Archiv 435(3): 365, Sept, 1999

Esophageal zinc content in human squamous esophageal cancer. Journal of the American College of Nutrition 6(1): 41-46, 1987