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Studies on monocyclic beta-lactam antibiotics. III. Synthesis and antibacterial activity of N-(aromatic heterocyclic substituted)azetidin-2-ones



Studies on monocyclic beta-lactam antibiotics. III. Synthesis and antibacterial activity of N-(aromatic heterocyclic substituted)azetidin-2-ones



Journal of Antibiotics 39(1): 76-89



The relationship between structure and antibacterial activity among monocyclic beta-lactams having a pyridyl, pyrimidinyl, thiazolyl, imidazolyl, or a tetrazolyl group at N-1 position was investigated. N-(Tetrazol-5-yl)azetidin-2-ones were found to posses excellent activity.

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Accession: 041460646

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PMID: 3949632

DOI: 10.7164/antibiotics.39.76


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