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Studies on monocyclic beta-lactam antibiotics. V. Synthesis and antibacterial activity of 3-[2- (2-aminothiazol-4-yl) - (Z) -2- (O-substituted oxyimino) -acetamido]-1- (1H-tetrazol-5-yl) -2-azetidinones having various functional groups at C-4 position of beta-lactam

Yoshida, C.; Tanaka, K.; Hattori, R.; Fukuoka, Y.; Komatsu, M.; Kishimoto, S.; Saikawa, I.

Journal of Antibiotics 39(2): 215-229

1986

ISSN/ISBN: 0021-8820
PMID: 3957788
Accession: 041460648
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The synthesis and antibacterial activity of the 3-[2-(2-aminothiazol-4-yl)-(Z)-2-(O-substituted oxyimino)acetamido]-1-(1H-tetrazol-5-yl)-2-azetidinones++ + having various functional groups at C-4 position of beta-lactam are described. These compounds exhibited a strong activity against a variety of Gram-negative bacteria including beta-lactamase-producing strains. Among various C-4 substituents explored, the fluoromethyl and carbamoyloxymethyl moiety were found to increase the activity.

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Related References

Yoshida, C.; Tanaka, K.; Hattori, R.; Fukuoka, Y.; Komatsu, M.; Kishimoto, S.; Saikawa, I. 1986: Studies on monocyclic beta-lactam antibiotics. V. Synthesis and antibacterial activity of 3-[2-(2-aminothiazol-4-yl)-(Z)-2-(O-substituted oxyimino)-acetamido]-1-(1H-tetrazol-5-yl)-2-azetidinones having various functional groups at C-4 position of beta-lactam Journal of Antibiotics 39(2): 215-229
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