Studies on the syntheses of sulfur containing pyrimido [5,4-d]pyrimidine derivatives. IV. The mechanism of dipyridamole formation from 4,8-dipiperidino-pyrimido [5,4-d]pyrimidine-2,6-disulfonyl dichloride and diethanolamine

Imai, K.; Kojima, T.; Tamazawa, K.; Takahashi, K.; Kawahara, S., 1976: Studies on the syntheses of sulfur containing pyrimido [5,4-d]pyrimidine derivatives. IV. The mechanism of dipyridamole formation from 4,8-dipiperidino-pyrimido [5,4-d]pyrimidine-2,6-disulfonyl dichloride and diethanolamine. Yakugaku Zasshi 96(5): 600-607

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Imai, K.; Ishida, T.; Horiguchi, H.; Ozasa, T.; Ohono, M.; Kawahara, S.; Murakami, M., 1976: Studies on the syntheses of sulfur containing pyrimido 5 4 d pyrimidine derivatives part 1 syntheses of pyrimido 5 4 d pyrimidine derivatives possessing methylsulfonyl or sulfonamide group at 2 position. Thirty-one kinds of pyrimido[5,4-d]pyrimidine derivatives possessing methylsulfonyl or sulfonamide group at 2-position were prepared by the reaction of 4,8-disubstituted 6-chloro-2-methylsulfonylpyrimido[5,4-d]pyrimidine or 4,8-disubstituted 6-chl...

Imai, K.; Ishida, T.; Horiguchi, H.; Ozasa, T.; Ohono, M., 1976: Studies on the syntheses of sulfur containing pyrimido [5,4-d]pyrimidine derivatives. I. Syntheses of pyrimido [5,4-D]pyrimidine derivatives possessing methylsulfonyl or sulfonamide group at 2-position. Yakugaku Zasshi 96(5): 578-585

Imai, K.; Ishida, T.; Ozasa, T.; Kawahara, S.; Murakami, M., 1976: Studies on the syntheses of sulfur containing pyrimido 5 4 d pyrimidine derivatives part 2 syntheses and rearrangement of 2 methylsulfonyl pyrimido 5 4 d pyrimidine 6 sulfonamide derivatives. In order to examine the relation between the structure and the activity of coronary vasodilation and inhibition of platelet aggregation [in dogs], 9 kinds of 2-methylsulfonylpyrimido-[5,4-d]pyrimidine derivatives possessing a sulfonamide group at...

Imai, K.; Ishida, T.; Ozasa, T.; Kawahara, S.; Murakami, M., 1976: Studies on the synthesis of sulfur containing pyrimido [5,4-d]pyrimidine derivatives. II. Syntheses and rearrangement of 2-methylsulfonyl pyrimido[5,4-d]pyrimidine-6-sulfonamide derivatives. Yakugaku Zasshi 96(5): 586-592

Imai, K.; Inukai, N.; Ishida, T.; Ozasa, T.; Kawahara, S., 1976: Studies on the syntheses of sulfur containing pyrimido [5,4-d]pyrimidine derivatives. III. A new synthesis of dipyridamole. Yakugaku Zasshi 96(5): 593-599

Malinka, W.; Zawisza, T.; Zajac, H.E., 1989: Syntheses and properties of selected derivatives of pyrimido[5,4-e]-1,3-thiazine and pyrimido[4,5-d]pyrimidine. In the reactions of ethyl 4-chloro/tosyloxy/-2-methylpyrimidine-5-carboxylate with differently substituted thioureas, new derivatives of 2,3-dihydro-7-methylpyrimido-[5,4-e]-1,3-thiazine (5-9) and of 7-methyl-1,2,3,4-tetrahydropyrimido[4,5-d]pyrim...

Mizoguchi M., 1972: Pyrimidine derivatives part 6 studies on the syntheses of orotic acid uracil and pyrimido 5 4 d pyrimidine derivatives. Yakugaku Zasshi: 785-795

Okui, K.; Mizoguchi, M., 1972: Pyrimidine derivatives. VI. Studies on the syntheses of orotic acid, uracil and pyrimido(5,4-d)pyrimidine derivatives. Yakugaku Zasshi 92(7): 785-795

Hashimoto, K.; Sano, N., 1968: Potentiation of the coronary vasodilator effect of norepinephrine by 2,6-bis (diethanolamino)-4,8-dipiperidino-pyrimido (5,4-d) pyrimidine (dipyridamole). Tohoku Journal of Experimental Medicine 96(2): 207-208

Yasuda, K.; Satoh, S.; Taira, N.; Hashimoto, K., 1968: Potentiation of norepinephrine and adenosine in the renal circulation by 2,6-bis (diethanolamino)-4,8-dipiperidino-pyrimido (5,4-d) pyrimidine (dipyridamole) treatment (preliminary report). Tohoku Journal of Experimental Medicine 96(2): 161-164