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Sulfhydryl groups are involved in the interaction of FSH with its receptor



Sulfhydryl groups are involved in the interaction of FSH with its receptor



Biochemical and Biophysical Research Communications 176(3): 1256-1261



FSH has recently been reported to possess thioredoxin-like activity, presumably explained by the homology between a region of FSH-beta subunit and the active site of thioredoxin. The homologous sequence lies within a receptor binding region, which suggests a possible role for sulfhydryl groups in the formation of an active hormone-receptor complex and subsequent signal transduction. In order to determine the relevance of sulfhydryl groups on FSH-receptor interaction, we studied the effect of N-ethylmaleimide (NEM) and glutathione on FSH binding. The results indicate that free sulfhydryl groups, probably derived from the FSH receptor, are involved in ligand-receptor interaction.

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Accession: 041487028

Download citation: RISBibTeXText

PMID: 1903937

DOI: 10.1016/0006-291x(91)90421-3


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