Section 42
Chapter 41,517

Synergistic interactions between the NMDA antagonist dizocilpine and the preferential dopamine autoreceptor antagonists (+) -AJ 76 and (+) -UH 232 with regard to locomotor stimulation in monoamine-depleted mice

Svensson, A.; Carlsson, M.; Carlsson, A.

Journal of Neural Transmission. General Section 85(1): 69-77


PMID: 1867840
DOI: 10.1007/bf01244659
Accession: 041516318

Download citation:  

When administered to mice pretreated with the monoamine-depleter reserpine and the catecholamine synthesis inhibitor alpha-methyl-para-tyrosine, the preferential autoreceptor antagonists (+)-AJ76 and (+)-UH 232 induced weak locomotor stimulation. When either (+)-AJ 76 or (+)-UH 232 was combined with a subthreshold dose of the selective NMDA antagonist dizocilpine (MK-801), a marked locomotor stimulation was produced in monoamine-depleted mice. The mechanism of this stimulation, although reduced by dopamine antagonists, remains to be clarified.

PDF emailed within 0-6 h: $19.90