EurekaMag Full Text Articles Chapter 41,519

Boryski, J.; Golankiewicz, B.; De Clercq, E. 1991: Synthesis and antiviral activity of 3-substituted derivatives of 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purines, tricyclic analogues of acyclovir and ganciclovir. Journal of Medicinal Chemistry 34(8): 2380-2383

Castro-Pichel, J.; García-López, M.T.; De las Heras, F.G.; Herranz, R.; Pérez, C.; Vilas, P. 1989: Synthesis and antiviral activity of 5'-O-(substituted) sulfamoyl pyrimidine nucleosides. Archiv der Pharmazie 322(1): 11-15

Lin, T.S.; Neenan, J.P.; Cheng, Y.C.; Prusoff, W.H. 1976: Synthesis and antiviral activity of 5- and 5'-substituted thymidine analogs. Journal of Medicinal Chemistry 19(4): 495-498

Wigerinck, P.; Snoeck, R.; Claes, P.; De Clercq, E.; Herdewijn, P. 1991: Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines. Journal of Medicinal Chemistry 34(6): 1767-1772

Harnden, M.R.; Jarvest, R.L.; Bacon, T.H.; Boyd, M.R. 1987: Synthesis and antiviral activity of 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]purines. Journal of Medicinal Chemistry 30(9): 1636-1642

Harnden, M.R.; Wyatt, P.G.; Boyd, M.R.; Sutton, D. 1990: Synthesis and antiviral activity of 9-alkoxypurines. 1. 9-(3-Hydroxypropoxy)- and 9-[3-hydroxymethyl)propoxy]purines. Journal of Medicinal Chemistry 33(1): 187-196

Bailey, S.; Harnden, M.R.; Jarvest, R.L.; Parkin, A.; Boyd, M.R. 1991: Synthesis and antiviral activity of 9-alkoxypurines. 2. 9-(2,3-Dihydroxypropoxy)-, 9-(3,4-dihydroxybutoxy)-, and 9-(1,4-dihydroxybut-2-oxy)purines. Journal of Medicinal Chemistry 34(1): 57-65

Iwashina, T.; Tovell, D.R.; Xu, L.; Tyrrell, D.L.; Knaus, E.E.; Wiebe, L.I. 1988: Synthesis and antiviral activity of IVFRU, a potential probe for the non-invasive diagnosis of herpes simplex encephalitis. Drug Design and Delivery 3(4): 309-321

Thompson, W.J.; Fitzgerald, P.M.; Holloway, M.K.; Emini, E.A.; Darke, P.L.; McKeever, B.M.; Schleif, W.A.; Quintero, J.C.; Zugay, J.A.; Tucker, T.J. 1992: Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents: X-ray crystal structure assisted design. Journal of Medicinal Chemistry 35(10): 1685-1701

Vandendriessche, F.; Snoeck, R.; Janssen, G.; Hoogmartens, J.; Van Aerschot, A.; De Clercq, E.; Herdewijn, P. 1992: Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain. Journal of Medicinal Chemistry 35(8): 1458-1465

Nagahara, M.; Kuriyama, K.; Hiyama, Y.; Ito, K.; Ikemoto, M.; Nakanishi, T. 1986: Synthesis and antiviral activity of bis(alkylaminoalkoxy-2-benzofuranyl)ketone derivatives and bis(acyloxy-2-benzofuranyl)ketone derivatives. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan 106(1): 27-35

Vince, R.; Turakhia, R.H.; Shannon, W.M.; Arnett, G. 1987: Synthesis and antiviral activity of carbocyclic analogues of xylofuranosides of 2-amino-6-substituted-purines and 2-amino-6-substituted-8-azapurines. Journal of Medicinal Chemistry 30(11): 2026-2030

Pudlo, J.S.; Saxena, N.K.; Nassiri, M.R.; Turk, S.R.; Drach, J.C.; Townsend, L.B. 1988: Synthesis and antiviral activity of certain 4- and 4,5-disubstituted 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidines. Journal of Medicinal Chemistry 31(11): 2086-2092

Saxena, N.K.; Hagenow, B.M.; Genzlinger, G.; Turk, S.R.; Drach, J.C.; Townsend, L.B. 1988: Synthesis and antiviral activity of certain 4-substituted and 2,4-disubstituted 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidines. Journal of Medicinal Chemistry 31(8): 1501-1506

Revankar, G.R.; Huffman, J.H.; Allen, L.B.; Sidwell, R.W.; Robins, R.K.; Tolman, R.L. 1975: Synthesis and antiviral activity of certain 5'-monophosphates of 9-D-arabinofuranosyladenine and 9-D-arabinofuranosylhypoxanthine. Journal of Medicinal Chemistry 18(7): 721-726

Kini, G.D.; Anderson, J.D.; Sanghvi, Y.S.; Lewis, A.F.; Smee, D.F.; Revankar, G.R.; Robins, R.K.; Cottam, H.B. 1991: Synthesis and antiviral activity of certain guanosine analogues in the thiazolo[4,5-d]pyrimidine ring system. Journal of Medicinal Chemistry 34(10): 3006-3010

Vaghefi, M.M.; McKernan, P.A.; Robins, R.K. 1986: Synthesis and antiviral activity of certain nucleoside 5'-phosphonoformate derivatives. Journal of Medicinal Chemistry 29(8): 1389-1393

Srivastava, P.C.; Pickering, M.V.; Allen, L.B.; Streeter, D.G.; Campbell, M.T.; Witkowski, J.T.; Sidwell, R.W.; Robins, R.K. 1977: Synthesis and antiviral activity of certain thiazole C-nucleosides. Journal of Medicinal Chemistry 20(2): 256-262

Tanaka, H.; Takashima, H.; Ubasawa, M.; Sekiya, K.; Nitta, I.; Baba, M.; Shigeta, S.; Walker, R.T.; De Clercq, E.; Miyasaka, T. 1992: Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents. Journal of Medicinal Chemistry 35(25): 4713-4719

Yu, K.L.; Bronson, J.J.; Yang, H.; Patick, A.; Alam, M.; Brankovan, V.; Datema, R.; Hitchcock, M.J.; Martin, J.C. 1992: Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine. Journal of Medicinal Chemistry 35(16): 2958-2969

Martin, J.A.; Bushnell, D.J.; Duncan, I.B.; Dunsdon, S.J.; Hall, M.J.; Machin, P.J.; Merrett, J.H.; Parkes, K.E.; Roberts, N.A.; Thomas, G.J. 1990: Synthesis and antiviral activity of monofluoro and difluoro analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1). Journal of Medicinal Chemistry 33(8): 2137-2145

Boryski, J.; Golankiewicz, B.; De Clercq, E. 1988: Synthesis and antiviral activity of novel N-substituted derivatives of acyclovir. Journal of Medicinal Chemistry 31(7): 1351-1355

Lambert, R.W.; Martin, J.A.; Thomas, G.J.; Duncan, I.B.; Hall, M.J.; Heimer, E.P. 1989: Synthesis and antiviral activity of phosphonoacetic and phosphonoformic acid esters of 5-bromo-2'-deoxyuridine and related pyrimidine nucleosides and acyclonucleosides. Journal of Medicinal Chemistry 32(2): 367-374

Keppeler, K.; De Clercq, E. 1987: Synthesis and antiviral activity of quinoxalinedione 2,3(1H, 4H) derivatives. Archiv der Pharmazie 320(3): 271-274

Bamford, M.J.; Coe, P.L.; Walker, R.T. 1990: Synthesis and antiviral activity of some 3'-C-difluoromethyl and 3'-deoxy-3'-C-fluoromethyl nucleosides. Journal of Medicinal Chemistry 33(9): 2488-2494

Saxena, N.K.; Coleman, L.A.; Drach, J.C.; Townsend, L.B. 1990: Synthesis and antiviral activity of some 7-[(2-hydroxyethoxy)methyl]pyrazolo[3,4-d]pyrimidine analogues of sangivamycin and toyocamycin. Journal of Medicinal Chemistry 33(7): 1980-1983

Bennett, S.M.; Nguyen-Ba, N.; Ogilvie, K.K. 1990: Synthesis and antiviral activity of some acyclic and C-acyclic pyrrolo[2,3-d]pyrimidine nucleoside analogues. Journal of Medicinal Chemistry 33(8): 2162-2173

Herdewijn, P.; De Clercq, E.; Balzarini, J.; Vanderhaeghe, H. 1985: Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines. Journal of Medicinal Chemistry 28(5): 550-555

Shealy, Y.F.; O'Dell, C.A.; Arnett, G.; Shannon, W.M. 1986: Synthesis and antiviral activity of the carbocyclic analogues of 5-ethyl-2'-deoxyuridine and of 5-ethynyl-2'-deoxyuridine. Journal of Medicinal Chemistry 29(1): 79-84

Balzarini, J.; Baumgartner, H.; Bodenteich, M.; De Clercq, E.; Griengl, H. 1989: Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine. Journal of Medicinal Chemistry 32(8): 1861-1865

Bronson, J.J.; Ghazzouli, I.; Hitchcock, M.J.; Webb, R.R.; Martin, J.C. 1989: Synthesis and antiviral activity of the nucleotide analogue (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine. Journal of Medicinal Chemistry 32(7): 1457-1463

Lin, T.S.; Guo, J.Y.; Schinazi, R.F.; Chu, C.K.; Xiang, J.N.; Prusoff, W.H. 1988: Synthesis and antiviral activity of various 3'-azido analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1, HTLV-III/LAV). Journal of Medicinal Chemistry 31(2): 336-340

Lin, T.S.; Chen, M.S.; McLaren, C.; Gao, Y.S.; Ghazzouli, I.; Prusoff, W.H. 1987: Synthesis and antiviral activity of various 3'-azido, 3'-amino, 2',3'-unsaturated, and 2',3'-dideoxy analogues of pyrimidine deoxyribonucleosides against retroviruses. Journal of Medicinal Chemistry 30(2): 440-444

Martin, J.C.; Tippie, M.A.; McGee, D.P.; Verheyden, J.P. 1987: Synthesis and antiviral activity of various esters of 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine. Journal of Pharmaceutical Sciences 76(2): 180-184

Srivastava, P.C.; Streeter, D.G.; Matthews, T.R.; Allen, L.B.; Sidwell, R.W. 1976: Synthesis and antiviral and antimicrobial activity of certain 1-beta-D-ribofuranosyl-4,5-disubstituted imidazoles. Journal of Medicinal Chemistry 19(8): 1020-1026

Mikhailopulo, I.A.; Poopeiko, N.E.; Pricota, T.I.; Sivets, G.G.; Kvasyuk, E.I.; Balzarini, J.; De Clercq, E. 1991: Synthesis and antiviral and cytostatic properties of 3'-deoxy-3'-fluoro- and 2'-azido-3'-fluoro-2',3'-dideoxy-D-ribofuranosides of natural heterocyclic bases. Journal of Medicinal Chemistry 34(7): 2195-2202

Kumar, R.; Xu, L.H.; Knaus, E.E.; Wiebe, L.I.; Tovell, D.R.; Tyrrell, D.L.; Allen, T.M. 1990: Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine. Journal of Medicinal Chemistry 33(2): 717-723

Heinisch, L.; Tonew, M.; Tonew, E. 1977: Synthesis and antiviral effect of N-heterocyclic formylisothiosemicarbazones. Die Pharmazie 32(12): 752-756

Willitzer, H.; Bräuniger, H.; Engelmann, D.; Krebs, D.; Ozegowski, W.; Tonew, M. 1978: Synthesis and antiviral effect of substituted 5-ureido and 5-thioureidobenzimidazole derivatives. Die Pharmazie 33(1): 30-38

Prisbe, E.J. 1986: Synthesis and antiviral evaluation of 1,4-dioxane nucleoside analogues related to nucleoside dialdehydes. Journal of Medicinal Chemistry 29(12): 2445-2450

Madhavan, G.V.; McGee, D.P.; Rydzewski, R.M.; Boehme, R.; Martin, J.C.; Prisbe, E.J. 1988: Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase. Journal of Medicinal Chemistry 31(9): 1798-1804

Rashan, L.J.; Ahmed, B.A.; Hussein, S.H.; al-Khayat, R.; al-Omar, L. 1989: Synthesis and antiviral evaluation of 6-p-ethylphenyl-5H-pyrrolo [3,4-b]pyridine-5,7-dione. Farmaco 44(9): 893-896

Gabrielsen, B.; Phelan, M.J.; Barthel-Rosa, L.; See, C.; Huggins, J.W.; Kefauver, D.F.; Monath, T.P.; Ussery, M.A.; Chmurny, G.N.; Schubert, E.M. 1992: Synthesis and antiviral evaluation of N-carboxamidine-substituted analogues of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine hydrochloride. Journal of Medicinal Chemistry 35(17): 3231-3238

Lin, T.S.; Zhang, X.H.; Wang, Z.H.; Prusoff, W.H. 1988: Synthesis and antiviral evaluation of carbocyclic analogues of 2'-azido- and 2'-amino-2'-deoxycytidine. Journal of Medicinal Chemistry 31(2): 484-486

Shealy, Y.F.; O'Dell, C.A.; Arnett, G. 1987: Synthesis and antiviral evaluation of carbocyclic analogues of 2-amino-6-substituted-purine 3'-deoxyribofuranosides. Journal of Medicinal Chemistry 30(6): 1090-1094

Alonso, R.; Andrés, J.I.; García-López, M.T.; de las Heras, F.G.; Herranz, R.; Alarcón, B.; Carrasco, L. 1985: Synthesis and antiviral evaluation of nucleosides of 5-methylimidazole-4-carboxamide. Journal of Medicinal Chemistry 28(6): 834-838

Patil, S.D.; Schneller, S.W.; Hosoya, M.; Snoeck, R.; Andrei, G.; Balzarini, J.; De Clercq, E. 1992: Synthesis and antiviral properties of (+/-)-5'-noraristeromycin and related purine carbocyclic nucleosides. a new lead for anti-human cytomegalovirus agent design. Journal of Medicinal Chemistry 35(18): 3372-3377

Jones, A.S.; Sayers, J.R.; Walker, R.T.; De Clercq, E. 1988: Synthesis and antiviral properties of (E)-5-(2-bromovinyl)-2'-deoxycytidine-related compounds. Journal of Medicinal Chemistry 31(1): 268-271

Mitchell, W.L.; Ravenscroft, P.; Hill, M.L.; Knutsen, L.J.; Judkins, B.D.; Newton, R.F.; Scopes, D.I. 1986: Synthesis and antiviral properties of 5-(2-substituted vinyl)-6-aza-2'-deoxyuridines. Journal of Medicinal Chemistry 29(5): 809-816

Ishizumi, K.; Kojima, A.; Antoku, F. 1991: Synthesis and anxiolytic activity of N-substituted cyclic imides (1R*,2S*,3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3- bicyclo[2.2.1]heptanedicarboximide (tandospirone) and related compounds. Chemical and Pharmaceutical Bulletin 39(9): 2288-2300

Gengenbacher, T.; Gerok, W.; Giese, U.; Kurz, G. 1990: Synthesis and applicability of photolabile 7,7-azo analogues of natural bile salt precursors. Journal of Lipid Research 31(2): 315-327

Ares, J.J.; Fowble, J.W.; Urchek, T.G.; Miller, D.D. 1987: Synthesis and application of 13C enriched phenylisothiocyanate as a 13C NMR protein probe. Biochemical and Biophysical Research Communications 142(3): 1064-1071

Zhang, R.E.; Cao, Y.L.; Hearn, M.W. 1991: Synthesis and application of Fmoc-hydrazine for the quantitative determination of saccharides by reversed-phase high-performance liquid chromatography in the low and subpicomole range. Analytical Biochemistry 195(1): 160-167

Müller, J.; Pfleiderer, G. 1978: Synthesis and application of a new bifunctional amidination reagent. Hoppe-Seyler's Zeitschrift für Physiologische Chemie 359(3): 407-411

Tanaka, T.; Yamada, Y.; Sakata, T.; Uesugi, S.; Ikehara, M. 1988: Synthesis and application of a new phosphorylating agent: S-(N-monomethoxytritylaminoethyl)-O-(o-chlorophenyl)phosphorothi oate. Nucleic Acids Symposium Series 19: 21-24

Sharp, K.A.; Yalpani, M.; Howard, S.J.; Brooks, D.E. 1986: Synthesis and application of a poly(ethylene glycol)-antibody affinity ligand for cell separations in aqueous polymer two-phase systems. Analytical Biochemistry 154(1): 110-117

Breipohl, G.; Knolle, J.; Stüber, W. 1989: Synthesis and application of acid labile anchor groups for the synthesis of peptide amides by Fmoc-solid-phase peptide synthesis. International Journal of Peptide and Protein Research 34(4): 262-267

Schramm, H.J.; Dülffer, T. 1977: Synthesis and application of cleavable and hydrophilic crosslinking reagents. Advances in Experimental Medicine and Biology 86a: 197-206

Gibson, K.J.; Benkovic, S.J. 1987: Synthesis and application of derivatizable oligonucleotides. Nucleic Acids Research 15(16): 6455-6467

Kelman, D.J.; Lilga, K.T.; Sharma, M. 1988: Synthesis and application of fluorescent labeled nucleotides to assay DNA damage. Chemico-Biological Interactions 66(1-2): 85-100

Trommer, W.E.; Friebel, K.; Kiltz, H.H.; Kolkenbrock, H.J. 1977: Synthesis and application of new bifunctional reagents. Advances in Experimental Medicine and Biology 86a: 187-195

Awad, I.M. 1992: Synthesis and application of novel sulpha drugs based on quinoxaline-2-one and/or quinoxaline-2-thione. Journal of Chemical Technology and Biotechnology 53(3): 227-236

Schäfer, R.; Nehls-Sahabandu, M.; Grabowsky, B.; Dehlinger-Kremer, M.; Schulz, I.; Mayr, G.W. 1990: Synthesis and application of photoaffinity analogues of inositol 1,4,5-trisphosphate selectively substituted at the 1-phosphate group. Biochemical Journal 272(3): 817-825

Bückmann, A.F.; Carrea, G. 1989: Synthesis and application of water-soluble macromolecular derivatives of the redox coenzymes NAD(H), NADP(H) and FAD. Advances in Biochemical Engineering/Biotechnology 39: 97-152

Filtz, T.M.; Chumpradit, S.; Kung, H.F.; Molinoff, P.B. 1990: Synthesis and applications of an aldehyde-containing analogue of SCH-23390. Bioconjugate Chemistry 1(6): 394-399

Beijer, B.; Sulston, I.; Sproat, B.S.; Rider, P.; Lamond, A.I.; Neuner, P. 1990: Synthesis and applications of oligoribonucleotides with selected 2'-O-methylation using the 2'-O-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl] protecting group. Nucleic Acids Research 18(17): 5143-5151

Aboul-Enein, H.Y. 1988: Synthesis and aromatase inhibiting activity of aminoglutethimide analogs. Drug Design and Delivery 2(3): 221-226

Hartmann, R.W.; Batzl, C.; Pongratz, T.M.; Mannschreck, A. 1992: Synthesis and aromatase inhibition of 3-cycloalkyl-substituted 3-(4-aminophenyl)piperidine-2,6-diones. Journal of Medicinal Chemistry 35(12): 2210-2214

Stanek, J.; Alder, A.; Bellus, D.; Bhatnagar, A.S.; Häusler, A.; Schieweck, K. 1991: Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones. Journal of Medicinal Chemistry 34(4): 1329-1334

Dintinger, T.; Gaillard, J.L.; Zwain, I.; Bouhamidi, R.; Silberzahn, P. 1989: Synthesis and aromatization of 19-norandrogens in the stallion testis. Journal of Steroid Biochemistry 32(4): 537-544

Atkinson, P.H. 1975: Synthesis and assembly of Hela cell plasma membrane glycoproteins and proteins. Journal of Biological Chemistry 250(6): 2123-2134

Sonderfeld-Fresko, S.; Proia, R.L. 1988: Synthesis and assembly of a catalytically active lysosomal enzyme, beta-hexosaminidase B, in a cell-free system. Journal of Biological Chemistry 263(26): 13463-13469

Ostman, A.; Rall, L.; Hammacher, A.; Wormstead, M.A.; Coit, D.; Valenzuela, P.; Betsholtz, C.; Westermark, B.; Heldin, C.H. 1988: Synthesis and assembly of a functionally active recombinant platelet-derived growth factor AB heterodimer. Journal of Biological Chemistry 263(31): 16202-16208

Leibowitz, J.; Horwitz, M.S. 1975: Synthesis and assembly of adenovirus polypeptides. III. Reversible inhibition of hexon assembly in adenovirus type 5 temperature-sensitive mutants. Virology 66(1): 10-24

Irving, R.A.; Toneguzzo, F.; Rhee, S.H.; Hofmann, T.; Ghosh, H.P. 1979: Synthesis and assembly of membrane glycoproteins: presence of leader peptide in nonglycosylated precursor of membrane glycoprotein of vesicular stomatitis virus. Proceedings of the National Academy of Sciences of the United States of America 76(2): 570-574

Lelievre, J.M.; Dickinson, C.D.; Dickinson, L.A.; Nielsen, N.C. 1992: Synthesis and assembly of soybean beta-conglycinin in vitro. Plant Molecular Biology 18(2): 259-274

Ito, K.; Sato, T.; Yura, T. 1977: Synthesis and assembly of the membrane proteins in E. coli. Cell 11(3): 551-559

Green, T.L.; Hunter, D.D.; Chan, W.; Merlie, J.P.; Sanes, J.R. 1992: Synthesis and assembly of the synaptic cleft protein S-laminin by cultured cells. Journal of Biological Chemistry 267(3): 2014-2022

Tanabe, M.; Harada, M.; Odawara, F.; Ikuta, S.; Nakagawa, N.; Otani, M. 1991: Synthesis and assignment of novel [125I]-labeled 1 alpha,25-dihydroxyvitamin D3 derivatives. Journal of Nutritional Science and Vitaminology 37(2): 139-147

Murphy, R.C.; Clay, K.L. 1979: Synthesis and back exchange of 18O labeled amino acids for use as internal standards with mass spectrometry. Biomedical Mass Spectrometry 6(7): 309-314

Bartczak, A.W.; Sangaiah, R.; Ball, L.M.; Warren, S.H.; Gold, A. 1987: Synthesis and bacterial mutagenicity of the cyclopenta oxides of the four cyclopenta-fused isomers of benzanthracene. Mutagenesis 2(2): 101-105

Ge, W.Y.; Xu, L.J. 1989: Synthesis and bacteriostatic activity of 2-furanthiocarboxyhydrazones and their transition metal complexes. Yao Xue Xue Bao 24(1): 27-31

Hou, N.; Xu, L.J. 1992: Synthesis and bacteriostatic activity of new thiosemicarbazone derivatives--amino mercaptotriazole Schiff bases. Yao Xue Xue Bao 27(10): 738-742

Debart, F.; Rayner, B.; Degols, G.; Imbach, J.L. 1992: Synthesis and base-pairing properties of the nuclease-resistant alpha-anomeric dodecaribonucleotide alpha-[r(UCUUAACCCACA). Nucleic Acids Research 20(6): 1193-1200

Francis, J.E.; Cash, W.D.; Barbaz, B.S.; Bernard, P.S.; Lovell, R.A.; Mazzenga, G.C.; Friedmann, R.C.; Hyun, J.L.; Braunwalder, A.F.; Loo, P.S. 1991: Synthesis and benzodiazepine binding activity of a series of novel [1,2,4]triazolo[1,5-c]quinazolin-5(6H)-ones. Journal of Medicinal Chemistry 34(1): 281-290

Dorey, G.; Poissonnet, G.; Potier, M.C.; Prado de Carvalho, L.; Venault, P.; Chapouthier, G.; Rossier, J.; Potier, P.; Dodd, R.H. 1989: Synthesis and benzodiazepine receptor affinities of rigid analogues of 3-carboxy-beta-carbolines: demonstration that the benzodiazepine receptor recognizes preferentially the s-cis conformation of the 3-carboxy group. Journal of Medicinal Chemistry 32(8): 1799-1804

Trapani, G.; Latrofa, A.; Franco, M.; Liso, G.; Genchi, G. 1990: Synthesis and benzodiazepine receptor binding of 1H-pyrrolo[2,1-C][1,4]benzothiazines. Farmaco 45(6): 577-588

Trapani, G.; Latrofa, A.; Franco, M.; Liso, G.; Genchi, G. 1990: Synthesis and benzodiazepine receptor binding of 5H-pyrido[2,1-C][1,4]benzothiazines. Farmaco 45(6): 589-602

Shimoji, Y.; Tomita, K.; Karube, T.; Kamioka, T. 1992: Synthesis and benzodiazepine receptor binding studies of pyridazino[3,4-b]indoles. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan 112(11): 804-816

Anzini, M.; Cappelli, A.; Vomero, S.; Cagnotto, A.; Skorupska, M. 1992: Synthesis and benzodiazepine receptors affinity of 2,3-dihydro-9-phenyl-1H-pyrrolo[3,4-b]quinolin-1-one and 3-carbethoxy-4-phenylquinoline derivatives. Farmaco 47(2): 191-202

Mauleón, D.; Pujol, M.D.; Rosell, G. 1988: Synthesis and beta-adrenergic antagonism of 2-(aryloxy)-1-(2-piperidyl)ethanols. Journal of Medicinal Chemistry 31(11): 2122-2126

Vo, D.; Wolowyk, M.W.; Knaus, E.E. 1991: Synthesis and beta-adrenergic antagonist activity of novel (3-cyanodihydropyridyl)propanolamines. Drug Design and Discovery 8(2): 157-164

Vo, D.; Wolowyk, M.W.; Knaus, E.E. 1992: Synthesis and beta-adrenergic antagonist activity of novel (3-oxazolinyl-1,4-dihydropyridyl) propanolamines. Drug Design and Discovery 8(4): 265-272

Leftheris, K.; Goodman, M. 1990: Synthesis and beta-adrenergic antagonist activity of stereoisomeric practolol and propranolol derivatives. Journal of Medicinal Chemistry 33(1): 216-223

Brack, A.; Caille, A. 1978: Synthesis and beta-conformation of copolypeptides with alternating hydrophilic and hydrophobic residues. International Journal of Peptide and Protein Research 11(2): 128-139

Nishimura, S.; Yasuda, N.; Sasaki, H.; Matsumoto, Y.; Kamimura, T.; Sakane, K.; Takaya, T. 1989: Synthesis and beta-lactamase inhibitory activity of 7 alpha-hydroxyethyl cephem derivatives. Journal of Antibiotics 42(1): 159-162

Nishimura, S.; Yasuda, N.; Sasaki, H.; Matsumoto, Y.; Kamimura, T.; Sakane, K.; Takaya, T. 1990: Synthesis and beta-lactamase inhibitory activity of 7 alpha-hydroxyethyl cephem sulfone and sulfoxide derivatives. Journal of Antibiotics 43(1): 114-117

Brooks, G.; Coleman, K.; Davies, J.S.; Hunter, P.A. 1988: Synthesis and beta-lactamase inhibitory activity of 9-(2-amidoethenylthio)-9-deoxy derivatives of clavulanic acid. Journal of Antibiotics 41(7): 892-898

Chen, Y.L.; Hedberg, K.; Barrett, J.F.; Retsema, J.A. 1988: Synthesis and beta-lactamase inhibitory activity of thiazolyl penam sulfones. Journal of Antibiotics 41(1): 134-138

Tanaka, H.; Tanaka, M.; Nakai, A.; Yamada, S.; Ishida, N.; Otani, T.; Torii, S. 1988: Synthesis and beta-lactamase inhibitory properties of 2 beta-(thio-substituted methyl)-penam 1,1-dioxides. Journal of Antibiotics 41(4): 579-582

Micetich, R.G.; Maiti, S.N.; Spevak, P.; Hall, T.W.; Yamabe, S.; Ishida, N.; Tanaka, M.; Yamazaki, T.; Nakai, A.; Ogawa, K. 1987: Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives. Journal of Medicinal Chemistry 30(8): 1469-1474

Gottstein, W.J.; Haynes, U.J.; McGregor, D.N. 1985: Synthesis and beta-lactamase inhibitory properties of 2 beta-[(acyloxy)methyl]-2-methylpenam-3 alpha-carboxylic acid 1,1-dioxides. Journal of Medicinal Chemistry 28(4): 518-522

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Horwell, D.C.; Beeby, A.; Clark, C.R.; Hughes, J. 1987: Synthesis and binding affinities of analogues of cholecystokinin-(30-33) as probes for central nervous system cholecystokinin receptors. Journal of Medicinal Chemistry 30(4): 729-732

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Jendralla, H.; Baader, E.; Bartmann, W.; Beck, G.; Bergmann, A.; Granzer, E.; von Kerekjarto, B.; Kesseler, K.; Krause, R.; Schubert, W. 1990: Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids. Journal of Medicinal Chemistry 33(1): 61-70

Jendralla, H.; Granzer, E.; von Kerekjarto, B.; Krause, R.; Schacht, U.; Baader, E.; Bartmann, W.; Beck, G.; Bergmann, A.; Kesseler, K. 1991: Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids. Journal of Medicinal Chemistry 34(10): 2962-2983

Boomgaarden, M.; Henklein, P.; Sohr, R.; Morgenstern, R.; Martinez, J.; Ott, T. 1990: Synthesis and biological activity of new cholecystokinin (CCK)-analogs with a special CCK-A receptor antagonistic effect. Die Pharmazie 45(5): 377-378

Garbay-Jaureguiberry, C.; Barsi, M.C.; Jacquemin-Sablon, A.; Le Pecq, J.B.; Roques, B.P. 1992: Synthesis and biological activity of new dimers in the 7H-pyrido[4,3-c] carbazole antitumor series. Journal of Medicinal Chemistry 35(1): 72-81

Levesque, C.; Merand, Y.; Dufour, J.M.; Labrie, C.; Labrie, F. 1991: Synthesis and biological activity of new halo-steroidal antiestrogens. Journal of Medicinal Chemistry 34(5): 1624-1630

Rinaldi, M.; Pecorari, P.; Costantino, L.; Provvisionato, A.; Malagoli, M.; Cermelli, C. 1992: Synthesis and biological activity of new heterocyclic structures: [1,3]thiazino[2,3-i]purine, thiazolo[3,2-c] [1,2,3]triazolo[4,5-e]pyrimidine and [1,2,3]triazolo [4', 5': 4,5] pyrimido[6,1-b][1,3]thiazine. Farmaco 47(10): 1315-1322

Kim, W.J.; Ko, K.Y.; Kim, H.; Oh, J. 1991: Synthesis and biological activity of novel 3-(2-propenyl)-cephalosporins. i. Journal of Antibiotics 44(10): 1073-1082

Kim, W.J.; Ko, K.Y.; Jung, M.H.; Kim, M.; Lee, K.I.; Kim, J.H. 1991: Synthesis and biological activity of novel 3-(2-propenyl)-cephalosporins. II. Preparation of prodrugs. Journal of Antibiotics 44(10): 1083-1087

Campbell, R.M.; Lee, Y.; Mowles, T.F.; McIntyre, K.W.; Ahmad, M.; Felix, A.M.; Heimer, E.P. 1992: Synthesis and biological activity of novel C-terminal-extended and biotinylated growth hormone-releasing factor (GRF) analogs. Peptides 13(4): 787-793

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Tomiyama, T.; Wakabayashi, S.; Yokota, M. 1989: Synthesis and biological activity of novel carbacyclins having bicyclic substituents on the omega-chain. Journal of Medicinal Chemistry 32(8): 1988-1996

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Harvison, P.J.; Kalman, T.I. 1992: Synthesis and biological activity of novel folic acid analogues: pteroyl-S-alkylhomocysteine sulfoximines. Journal of Medicinal Chemistry 35(7): 1227-1233

Marasco, C.J.; Piantadosi, C.; Meyer, K.L.; Morris-Natschke, S.; Ishaq, K.S.; Small, G.W.; Daniel, L.W. 1990: Synthesis and biological activity of novel quaternary ammonium derivatives of alkylglycerols as potent inhibitors of protein kinase C. Journal of Medicinal Chemistry 33(3): 985-992

Gill, H.S.; Londowski, J.M.; Corradino, R.A.; Zinsmeister, A.R.; Kumar, R. 1990: Synthesis and biological activity of novel vitamin D analogues: 24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D3 and 24,24-difluoro-1 alpha,25-dihydroxy-26,27-dimethylvitamin D3. Journal of Medicinal Chemistry 33(2): 480-490

Danho, W.; Makofske, R.C.; Swistok, J.; Michalewsky, J.; Gabriel, T.; Marks, N.; Berg, M.J.; Baird, L.; Geiler, V.; Mackie, G. 1991: Synthesis and biological activity of novel, potent and long-acting analogs of AC-CCK-7 with high affinity for peripheral (type A) receptors. Peptide Research 4(2): 59-65

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Carboni, S.; Da Settimo, A.; Bertini, D.; Ferrarini, P.L.; Livi, O.; Tonetti, I. 1975: Synthesis and biological activity of pyrido(2,3-e)-1,4-diazepine and of pyrido(2,3-b)(1,4)diazepine. Il Farmaco; Edizione Scientifica 30(4): 238-247

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Märki, F.; de Gasparo, M.; Eisler, K.; Kamber, B.; Riniker, B.; Rittel, W.; Sieber, P. 1979: Synthesis and biological activity of seventeen analogues of human insulin. Hoppe-Seyler's Zeitschrift für Physiologische Chemie 360(11): 1619-1632

Lin, T.S.; Zhou, R.X.; Scanlon, K.J.; Brubaker, W.F.; Lee, J.J.; Woods, K.; Humphreys, C.; Prusoff, W.H. 1986: Synthesis and biological activity of several amino nucleoside-platinum(II) complexes. Journal of Medicinal Chemistry 29(5): 681-686

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Hishmat, O.; Abdel-Kerim, M.G.; Wassef, M.E.; Shalash, M.R.; Ismail, I. 1977: Synthesis and biological activity of some coumarin and furocoumarin derivatives. Pharmaceutica Acta Helvetiae 52(10): 252-255

Cavalleri, B.; Turconi, M.; Tamborini, G.; Occelli, E.; Cietto, G.; Pallanza, R.; Scotti, R.; Berti, M.; Romanó, G.; Parenti, F. 1990: Synthesis and biological activity of some derivatives of rifamycin P. Journal of Medicinal Chemistry 33(5): 1470-1476

Ramalingam, K.; Thyvelikakath, G.X.; Berlin, K.D.; Chesnut, R.W.; Brown, R.A.; Durham, N.N.; Ealick, S.E.; van der Helm, D. 1977: Synthesis and biological activity of some derivatives of thiochroman-4-one and tetrahydrothiapyran-4-one. Journal of Medicinal Chemistry 20(6): 847-850

Malabarba, A.; Trani, A.; Ferrari, P.; Pallanza, R.; Cavalleri, B. 1987: Synthesis and biological activity of some esters of the N-acetylglucosaminyl aglycone and of the aglycone of teicoplanin. Journal of Antibiotics 40(11): 1572-1587

Bhatt, T.S. 1988: Synthesis and biological activity of some further cyclopenta[a]phenanthrenes. Carcinogenesis 9(9): 1669-1672

Varga, L.; Horvat, S.; Lemieux, C.; Schiller, P.W. 1987: Synthesis and biological activity of some glucose-enkephalin conjugates. International Journal of Peptide and Protein Research 30(3): 371-378

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El-Sayed Bayoumy, B. 1991: Synthesis and biological activity of some new 5-hydrothiazolo[4,3-b]-1,3,4-oxa(thia)diazoles and 5-hydrothiazolo[3,4-b]-1,2,4-triazoles containing 1,2,3-selena(thia)diazole moiety. Acta Poloniae Pharmaceutica 48(1-2): 13-18

Revankar, G.R.; Robins, R.K. 1975: Synthesis and biological activity of some nucleosides resembling guanosine: imidazo(1,2-alpha)pyrimidine nucleosides. Annals of the new York Academy of Sciences 255: 166-176

Rodriguez, M.; Galas, M.C.; Lignon, M.F.; Mendre, C.; Laur, J.; Aumelas, A.; Martinez, J. 1989: Synthesis and biological activity of some partially modified retro-inverso analogues of cholecystokinin. Journal of Medicinal Chemistry 32(10): 2331-2339

Shoeb, H.A.; Korkor, M.I. 1979: Synthesis and biological activity of some quinoline acrylamides. Research Communications in Chemical Pathology and Pharmacology 23(2): 367-373

Bühlmayer, P.; Caselli, A.; Fuhrer, W.; Göschke, R.; Rasetti, V.; Rüeger, H.; Stanton, J.L.; Criscione, L.; Wood, J.M. 1988: Synthesis and biological activity of some transition-state inhibitors of human renin. Journal of Medicinal Chemistry 31(9): 1839-1846

Sinha, B.K.; Chignell, C.F. 1975: Synthesis and biological activity of spin-labeled analogs of biotin, hexamethonium, decamethonium, dichlorisoproterenol, and propranolol. Journal of Medicinal Chemistry 18(7): 669-673

Poulos, C.; Brown, J.R.; Jordan, C.C. 1986: Synthesis and biological activity of substance P C-terminal hexapeptide analogues: structure-activity studies. Journal of Medicinal Chemistry 29(7): 1281-1284

Stavropoulos, G.; Karagiannis, K.; Cordopatis, P.; Halle, D.; Gilon, C.; Bar-Akiva, G.; Selinger, Z.; Chorev, M. 1991: Synthesis and biological activity of substance P C-terminal hexapeptide and heptapeptide analogues. International Journal of Peptide and Protein Research 37(3): 180-184

Haro, I.; Torres, J.L.; Valencia, G.; García-Antón, J.M.; Reig, F. 1989: Synthesis and biological activity of substance P analogues. International Journal of Peptide and Protein Research 33(5): 335-339

Woulfe, S.R.; Miller, M.J. 1985: Synthesis and biological activity of substituted [[3(S)-(acylamino)-2-oxo-1-azetidinyl]oxy]acetic acids. a new class of heteroatom-activated beta-lactam antibiotics. Journal of Medicinal Chemistry 28(10): 1447-1453

Ukai, S.; Hirose, K.; Kayano, M. 1975: Synthesis and biological activity of sulfur containing derivatives of chalcone. IV. a novel method for the synthesis of thioaurones. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan 95(3): 299-303

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Petiunin, P.A.; Alim, A.A.; Bannyĭ, I.P.; Timasheva, I.N. 1976: Synthesis and biological activity of the arensulfohydrazides of D-(MINUS)- AND OF L-(+)threo-1 (n-nitrophenyl)-1,3-dioxyisopropyloxamic acids. Farmatsevtychnyi Zhurnal 2: 35-40

Weber, U.; Schmid, H. 1976: Synthesis and biological activity of the decapeptide Gly-Pro-Cys-Lys-Ala-Arg-Phe-Gly-Gly-Cys as a model for the active center of the basic trypsin inhibitor from bovine organs (Kunitz inhibitor). Hoppe-Seyler's Zeitschrift für Physiologische Chemie 357(10): 1359-1363

Howson, W.; Kitteringham, J.; Mistry, J.; Mitchell, M.B.; Novelli, R.; Slater, R.A.; Swayne, G.T. 1988: Synthesis and biological activity of the four stereoisomers of 6-[4-[3-[[2-hydroxy-3-[4-[2- (cyclopropylmethoxy)ethyl]phenoxy]propyl]amino]-propionamido] phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone, a combined vasodilator and beta-adrenoceptor antagonist. Journal of Medicinal Chemistry 31(2): 352-356

Kinsey, B.M.; Fayad, F.; Venkateshan, C.N.; Adelstein, S.J.; Kassis, A.I. 1990: Synthesis and biological activity of the intercalating agent 3-acetamido-5-[123/125I]iodo-6-aminoacridine. International Journal of Radiation Applications and Instrumentation. Part B Nuclear Medicine and Biology 17(3): 341-346

Yamawaki, I.; Ogawa, K. 1988: Synthesis and biological activity of the metabolites of [3,4-bis(4-methoxyphenyl)-5-isoxazolyl]acetic acid. Chemical and Pharmaceutical Bulletin 36(8): 3142-3146

Rocherolle, V.; Olesker, A.; Lukacs, G. 1989: Synthesis and biological activity of the two isomeric 2'-C-methyl daunomycins. Journal of Antibiotics 42(9): 1393-1397

Brown, T.J.; Chapman, R.F.; Cook, D.C.; Hart, T.W.; McLay, I.M.; Jordan, R.; Mason, J.S.; Palfreyman, M.N.; Walsh, R.J.; Withnall, M.T. 1992: Synthesis and biological activity of trans(+-)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (RP 49356) and analogues: a new class of potassium channel opener. Journal of Medicinal Chemistry 35(20): 3613-3624

Stabinsky, Y.; Fridkin, M.; Zakuth, V.; Spirer, Z. 1978: Synthesis and biological activity of tuftsin and of [O = C Thr1]-tuftsin. a novel synthetic route to peptides containing N-terminal L -O = C Thr and L - O = C Ser residues. International Journal of Peptide and Protein Research 12(3): 130-138

Sieber, P.; Eisler, K.; Kamber, B.; Riniker, B.; Rittel, W.; Märki, F.; de Gasparo, M. 1978: Synthesis and biological activity of two disulphide bond isomers of human insulin: [A7-A11,A6-B7-cystine]- and [A6-A7,A11-B7-cystine]insulin (human). Hoppe-Seyler's Zeitschrift für Physiologische Chemie 359(1): 113-123

Cavalleri, B.; Volpe, G.; Arioli, V.; Lancini, G. 1977: Synthesis and biological activity of two metabolites of 1-methyl-5-(1-methylethyl)-2-nitro-1 H-imidazole, an antiprotozoal agent. Journal of Medicinal Chemistry 20(11): 1522-1525

Kinjo, J.E.; Pabuccuoglu, A.; Alster, D.K.; Lesiak, K.; Torrence, P.F. 1992: Synthesis and biological activity of uronic acid analogues of 2-5A[5'-O-triphosphoryladenylyl(2----5')adenylyl-(2'----5')adenosine. Drug Design and Discovery 8(3): 241-254

Goghari, M.H.; DeLean, A.; Garcia, R.; Cantin, M.; Schiller, P.W. 1990: Synthesis and biological activity profiles of atrial natriuretic factor (ANF) analogs. International Journal of Peptide and Protein Research 36(2): 156-160

Vázquez-Alcántara, M.A.; Juárez-Oropeza, M.A.; Zamora, R.M.; Díaz-Zagoya, J.C.; Garza-Flores, J. 1985: Synthesis and biological assessment of long-acting estradiol fatty acid esters in ovariectomized rats. Journal of Steroid Biochemistry 23(5a): 599-602

Wellmann, F.; Abraham, R.; Müller, R.; Gabel, D. 1991: Synthesis and biological behavior of a boronated analogue of the antiestrogen U 23,469-M. Zeitschrift für Naturforschung. C Journal of Biosciences 46(3-4): 252-256

Bormans, G.; Cleynhens, B.; José, D.; Hoogmartens, M.; De Roo, M.; Verbruggen, A. 1990: Synthesis and biological characteristics of the four stereoisomers of 99mTc-N,N'-bis-(mercaptoacetyl)-2,3-diaminopropanoate. International Journal of Radiation Applications and Instrumentation. Part B Nuclear Medicine and Biology 17(5): 499-506

Tanaka, S.; Robinson, E.A.; Yoshimura, T.; Matsushima, K.; Leonard, E.J.; Appella, E. 1988: Synthesis and biological characterization of monocyte-derived neutrophil chemotactic factor. Febs Letters 236(2): 467-470

Kanne, D.B.; Abood, L.G. 1988: Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids. Journal of Medicinal Chemistry 31(3): 506-509

Lambrecht, G. 1976: Synthesis and biological effect of enantiomeric 3-acetoxyquinuclidines. Archiv der Pharmazie 309(3): 235-239

Wisterowicz, K.; Foks, H.; Strzałkowska-Grad, H.; Hać, E.; Janowiec, M.; Zwolska-Kwiek, Z. 1986: Synthesis and biological effect of various derivatives of 2-imidazolidinoacetonitrile. Acta Poloniae Pharmaceutica 43(1): 25-31

Chou, T.C.; Kong, X.B.; Fanucchi, M.P.; Cheng, Y.C.; Takahashi, K.; Watanabe, K.A.; Fox, J.J. 1987: Synthesis and biological effects of 2'-fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil. Antimicrobial Agents and ChemoTherapy 31(9): 1355-1358

Kerekes, P.; Sharma, P.N.; Brossi, A.; Chignell, C.F.; Quinn, F.R. 1985: Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. new synthesis of thiodemecolcine and antileukemic effects of 2-demethyl- and 3-demethylthiocolchicine. Journal of Medicinal Chemistry 28(9): 1204-1208

Yevich, J.P.; New, J.S.; Smith, D.W.; Lobeck, W.G.; Catt, J.D.; Minielli, J.L.; Eison, M.S.; Taylor, D.P.; Riblet, L.A.; Temple, D.L. 1986: Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents. Journal of Medicinal Chemistry 29(3): 359-369

Grier, N.; Strelitz, R.A. 1976: Synthesis and biological evaluation of 1-(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)pyridinium hydroxide inner salt derivatives. Journal of Pharmaceutical Sciences 65(4): 616-618

Carroll, F.I.; Hauser, F.M.; Huffman, R.C.; Coleman, M.C. 1978: Synthesis and biological evaluation of 10-oxa-11-deoxyprostaglandin E1 and 10-nor-9,11-secoprostaglandin F1 and their derivatives. Journal of Medicinal Chemistry 21(4): 321-325

Schmidhammer, H.; Burkard, W.P.; Eggstein-Aeppli, L.; Smith, C.F. 1989: Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist. Journal of Medicinal Chemistry 32(2): 418-421

Schmidhammer, H.; Smith, C.F.; Erlach, D.; Koch, M.; Krassnig, R.; Schwetz, W.; Wechner, C. 1990: Synthesis and biological evaluation of 14-alkoxymorphinans. 3. Extensive study on cyprodime-related compounds. Journal of Medicinal Chemistry 33(4): 1200-1206

Kanojia, R.M. 1977: Synthesis and biological evaluation of 2 - and 4- hydroxymestranol. Steroids 30(3): 343-348

Terao, S.; Ohkawa, S.; Terashita, Z.; Shibouta, Y.; Nishikawa, K. 1991: Synthesis and biological evaluation of 2,3,5-trimethyl-6-(3-pyridylmethyl)-1,4-benzoquinone (CV-6504), a dual inhibitor of TXA2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species (AOS). Advances in Prostaglandin Thromboxane and Leukotriene Research 21a: 173-176

Stewart, J.T.; Gammans, R.E. 1975: Synthesis and biological evaluation of 2-(9-acridinyl)ethyl-N-substituted carbamates and their hydrochlorides and 10-N-oxides. Journal of Pharmaceutical Sciences 64(6): 1061-1063

Jiang, J.B.; Hesson, D.P.; Dusak, B.A.; Dexter, D.L.; Kang, G.J.; Hamel, E. 1990: Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization. Journal of Medicinal Chemistry 33(6): 1721-1728

Demopoulos, V.J.; Tani, E.; Long, J.P. 1989: Synthesis and biological evaluation of 3-(2-aminoethyl)pyrrole derivatives. Archiv der Pharmazie 322(11): 827-828

Matsukuma, I.; Yoshiiye, S.; Mochida, K.; Hashimoto, Y.; Sato, K.; Okachi, R.; Hirata, T. 1989: Synthesis and biological evaluation of 3-chloro-1-carbacephem compounds. Chemical and Pharmaceutical Bulletin 37(5): 1239-1244

Hughes, P.; DeVirgilio, J.; Humber, L.G.; Chau, T.; Weichman, B.; Neuman, G. 1989: Synthesis and biological evaluation of 4,6-diethyl-1,3,4,5-tetrahydropyrano[4,3-b]indole-4-acetic acid, an isomer of etodolac. Journal of Medicinal Chemistry 32(9): 2134-2137

Kawase, M.; Sinhababu, A.K.; McGhee, E.M.; Milby, T.; Borchardt, R.T. 1990: Synthesis and biological evaluation of 4-fluoro-, 7-fluoro-, and 4,7-difluoro-5,6-dihydroxytryptamines. Journal of Medicinal Chemistry 33(8): 2204-2211

Peterson, M.L.; Vince, R. 1991: Synthesis and biological evaluation of 4-purinylpyrrolidine nucleosides. Journal of Medicinal Chemistry 34(9): 2787-2797

Peterson, E.M.; Brownell, J.; Vince, R. 1992: Synthesis and biological evaluation of 5'-sulfamoylated purinyl carbocyclic nucleosides. Journal of Medicinal Chemistry 35(22): 3991-4000

Singh, S.K.; Dev, I.K.; Duch, D.S.; Ferone, R.; Smith, G.K.; Freisheim, J.H.; Hynes, J.B. 1991: Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues. Journal of Medicinal Chemistry 34(2): 606-610

DeGraw, J.I.; Colwell, W.T.; Brown, V.H.; Sato, M.; Kisliuk, R.L.; Gaumont, Y.; Thorndike, J.; Sirotnak, F.M. 1988: Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative. Journal of Medicinal Chemistry 31(1): 150-153

Kam, S.T.; Portoghese, P.S.; Gerrard, J.M.; Dunham, E.W. 1979: Synthesis and biological evaluation of 9,11-azo-13-oxa-15-hydroxyprostanoic acid, a potent inhibitor of platelet aggregation. Journal of Medicinal Chemistry 22(11): 1402-1408

Farquhar, D.; Smith, R. 1985: Synthesis and biological evaluation of 9-[5'-(2-oxo-1,3,2-oxazaphosphorinan-2-yl)-beta-D-arabinosyl]ade nine and 9-[5'-(2-oxo-1,3,2-dioxaphosphorinan-2-yl)-beta-D-arabinosyl]ade nine: potential neutral precursors of 9-[beta-D-arabinofuranosyl]adenine 5'-monophosphate. Journal of Medicinal Chemistry 28(9): 1358-1361

Singh, S.K.; Singer, S.C.; Ferone, R.; Waters, K.A.; Mullin, R.J.; Hynes, J.B. 1992: Synthesis and biological evaluation of N alpha-(5-deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine. Journal of Medicinal Chemistry 35(11): 2002-2006

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Wilson, A.A.; Dannals, R.F.; Ravert, H.T.; Frost, J.J.; Wagner, H.N. 1989: Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist. Journal of Medicinal Chemistry 32(5): 1057-1062

Saji, H.; Tsutsumi, D.; Kiso, Y.; Iimuma, S.; Mimoto, T.; Akaji, K.; Magata, Y.; Nakamura, H.; Kita, A.; Konishi, J. 1992: Synthesis and biological evaluation of a 13N-labeled opioid peptide. International Journal of Radiation Applications and Instrumentation. Part B Nuclear Medicine and Biology 19(4): 455-460

Day, B.W.; Magarian, R.A.; Jain, P.T.; Pento, J.T.; Mousissian, G.K.; Meyer, K.L. 1991: Synthesis and biological evaluation of a series of 1,1-dichloro-2,2,3-triarylcyclopropanes as pure antiestrogens. Journal of Medicinal Chemistry 34(2): 842-851

Griffin, M.T.; Magarian, R.A.; Jain, P.; Pento, J.T.; Mousissian, G.K.; Graves, D.C. 1992: Synthesis and biological evaluation of a series of gem-dichlorocyclopropanes as antitumor agents. Anti-Cancer Drug Design 7(1): 49-66

Brown, R.F.; Kinnick, M.D.; Morin, J.M.; Vasileff, R.T.; Counter, F.T.; Davidson, E.O.; Ensminger, P.W.; Eudaly, J.A.; Kasher, J.S.; Katner, A.S. 1990: Synthesis and biological evaluation of a series of parenteral 3'-quaternary ammonium cephalosporins. Journal of Medicinal Chemistry 33(8): 2114-2121

Hrib, N.J.; Jurcak, J.G.; Huger, F.P.; Errico, C.L.; Dunn, R.W. 1991: Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents. Journal of Medicinal Chemistry 34(3): 1068-1072

Johnson, R.L.; Bontems, R.J.; Yang, K.E.; Mishra, R.K. 1990: Synthesis and biological evaluation of analogues of Pro-Leu-Gly-NH2 modified at the leucyl residue. Journal of Medicinal Chemistry 33(6): 1828-1832

Peterson, M.L.; Vince, R. 1990: Synthesis and biological evaluation of carbocyclic analogues of lyxofuranosides of 2-amino-6-substituted-purines and 2-amino-6-substituted-8-azapurines. Journal of Medicinal Chemistry 33(4): 1214-1219

Kang, Y.; Larson, S.B.; Robins, R.K.; Revankar, G.R. 1989: Synthesis and biological evaluation of certain 3-beta-D-ribofuranosyl-1,2,4-triazolo[4,3-b)pyridazines related to formycin prepared via ring closure of pyridazine precursors. Journal of Medicinal Chemistry 32(7): 1547-1551

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Pinas, N.; Poulos, C.P.; Theodoropoulos, D. 1979: Synthesis and biological properties of the [5-(N5-dimethyl)-glutamine]-analogue of the C-terminal heptapeptide of substance P: active-site studies. Febs Letters 108(1): 45-46

Packard, A.B.; Srivastava, S.C.; Richards, P.; Meinken, G.E.; Ford, L.; Benson, W.R. 1989: Synthesis and biological properties of the lipophilic technetium-99m complex 99mTc(acac)3. International Journal of Radiation Applications and Instrumentation. Part B Nuclear Medicine and Biology 16(3): 291-294

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Bhattacharjee, A.K.; Sadoff, J.C.; Collins, H.; Cross, A.S.; Khalil, A.H.; Bieber, M.M.; Wright, C.; Teng, N.N. 1990: Synthesis and characterization of gentiobiose heptaacetate conjugate vaccines that produce endotoxin-neutralizing antibodies. Bioconjugate Chemistry 1(6): 375-380

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Hashimoto, K.; Loader, J.E.; Kinsky, S.C. 1985: Synthesis and characterization of methotrexate-dimyristoylphosphatidylethanolamine derivatives and the glycerophosphorylethanolamine analogs. Biochimica et Biophysica Acta 816(1): 163-168

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Berset, J.D.; Krebs, A. 1990: Synthesis and characterization of new 10-acylderivatives of the antipsoriatic agent dithranol: coupling products of dithranol with all-trans-retinoic acid, 13-cis-retinoid acid and an aromatic analogue of retinoic acid: all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl- nona-2,4,6,8-tetraenoate. Pharmaceutica Acta Helvetiae 65(11): 290-297

Ergenç, N.; Ozçekiç, H. 1988: Synthesis and characterization of new 2-(arylidenehydrazino)-4-methyl-5-(arylazo)thiazoles. Die Pharmazie 43(12): 832-834

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Al-Alaf, T.A.; Ayoub, M.T.; Rashan, L.J. 1990: Synthesis and characterization of novel biologically active platinum(II) and palladium(II) complexes of some beta-carboline alkaloids. Journal of Inorganic Biochemistry 38(1): 47-56

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Piao, A.Z.; Nojiri, C.; Park, K.D.; Jacobs, H.; Feijen, J.; Kim, S.W. 1990: Synthesis and characterization of poly(dimethylsiloxane)-poly(ethylene oxide)-heparin CBABC type block copolymers. Journal of Biomaterials Science. Polymer Edition 1(4): 299-313

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Waugh, K.M.; Berlin, K.D.; Ford, W.T.; Holt, E.M.; Carrol, J.P.; Schomber, P.R.; Thompson, M.D.; Schiff, L.J. 1985: Synthesis and characterization of selected heteroarotinoids. Pharmacological activity as assessed in vitamin a deficient hamster tracheal organ cultures. Single-crystal X-ray diffraction analysis of 4,4-dimethylthiochroman-6-yl methyl ketone 1,1-dioxide and ethyl (E)-p-[2-(4,4-dimethylthiochroman-6-yl)propenyl]benzoate. Journal of Medicinal Chemistry 28(1): 116-124

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Lepre, C.A.; Chassot, L.; Costello, C.E.; Lippard, S.J. 1990: Synthesis and characterization of trans-[Pt(NH3)2Cl2] adducts of d(CCTCGAGTCTCC).d(GGAGACTCGAGG). Biochemistry 29(3): 811-823

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Thimmaiah, K.N.; Horton, J.K.; Seshadri, R.; Israel, M.; Houghton, J.A.; Harwood, F.C.; Houghton, P.J. 1992: Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells. Journal of Medicinal Chemistry 35(18): 3358-3364

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Gundermann, K.D.; Lieske, D.; Haase, B.; Hartmann-Azanza Baca, B. 1987: Synthesis and chemiluminescence of copolymers of 5-amino-8-vinyl-phthalazine-1,4(2H,3H)-dione with methyl methacrylate or styrene, and of alpha, omega-bis[5-amino-phthalazine-1,4(2H,3H)-dion-]8-yl alkanes [= alpha, omega-bis(6-luminyl) alkanes]: investigations on an intramolecular 'distance effect'. Journal of Bioluminescence and Chemiluminescence 1(4): 201-213

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Grella, G.; Paglietti, G.; Sparatore, F.; Manca, P.; Satta, M. 1987: Synthesis and choleretic activity of 3-(2-aryl-5R-benzimidazol-1-yl) butanoic acids. Il Farmaco; Edizione Scientifica 42(7): 475-490

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Blarzino, C.; Foppoli, C.; Coccia, R. 1987: Synthesis and chromatographic properties of S-(1-carboxyethyl)-L-cysteine and S-(1-carboxypropyl)-L-cysteine. Italian Journal of Biochemistry 36(1): 1-7

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Rinaldi, A.; Dernini, S.; Fadda, M.B.; De Marco, C. 1975: Synthesis and chromatographic properties of cysthationamine. a substrate for diamineoidase. Italian Journal of Biochemistry 24(3-4): 207-218

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Helbecque, N.; Loucheux-Lefebvre, M.H. 1978: Synthesis and circular dichroism studies of two polypeptides H-[Gly-(Pro)3]n-OH and H-[Gly-(Pro)4]n-OH. International Journal of Peptide and Protein Research 11(5): 353-362

Morgan, T.K.; Wohl, R.A.; Lumma, W.C.; Wan, C.N.; Davey, D.D.; Gomez, R.P.; Marisca, A.J.; Briggs, M.; Sullivan, M.E.; Wong, S.S. 1986: Synthesis and class IIi antiarrhythmic activity of (phenylbut-2-enyl)ammonium salts. Effect of conformation on activity. Journal of Medicinal Chemistry 29(8): 1398-1405

Gerbes, A.L. 1992: Synthesis and clearance of atrial natriuretic factor in cirrhosis. Journal of Hepatology 15(3): 419-420

Gorodetskiĭ, S.I.; Kiarshulite, D.R.; Ivanov, V.N.; Kapelinskaia, T.V.; Kaledin, A.S. 1985: Synthesis and cloning of DNA complementary to mRNA of the bovine mammary gland. Genetika 21(2): 191-200

Shang, F.R.; Huang, H.L.; Song, H.Y.; Chen, H.; Yang, Z.X. 1989: Synthesis and cloning of V gamma 3 cDNA of monoclonal antibody. Yi Chuan Xue Bao 16(3): 213-218

Siniakov, A.N.; Serpinskiĭ, O.I.; Daniliuk, N.K. 1986: Synthesis and cloning of a DNA fragment containing a probable site for eukaryotic mRNA binding to ribosome. Bioorganicheskaia Khimiia 12(5): 655-660

Hoffmann, S.; Günther, E.; Kunze, G.; Bärwolff, D.; Teppke, M.; Barth, A. 1987: Synthesis and cloning of a human beta-casomorphin-5 gene. Nucleic Acids Symposium Series 18: 229-232

Xu, N.Z.; Shang, F.R. 1988: Synthesis and cloning of lengthy cDNA segments of 3'-poly(A)-RNA virus. Yi Chuan Xue Bao 15(5): 382-388

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Altomare, C.; Carotti, A.; Casini, G.; Cellamare, S.; Ferappi, M.; Gavuzzo, E.; Mazza, F.; Pantaleoni, G.; Giorgi, R. 1988: Synthesis and cognition activating properties of some mono- and bicyclic lactam derivatives. Journal of Medicinal Chemistry 31(11): 2153-2158

Jánoki, G.A.; Harwig, J.F.; Wolf, W. 1988: Synthesis and comparative biodistribution of the desferrioxamine-human serum albumin (DF-HSA) conjugates prepared with various methods. Journal of Nuclear Medicine and Allied Sciences 32(1): 39-44

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Ghysdael, J.; Hubert, E.; Travinicek, M.; Bolognesi, D.P.; Cleuter, Y.; Huex, G.; Marbaix, G.; Portetelle, D.; Chantrenne, H. 1977: Synthesis and complete processing of a high-molecular-weight precursor polypeptide to viral structural proteins in toad oocytes micro-injected with avian myeloblastosis virus ribonucleic acid. Biochemical Society Transactions 5(4): 950-953

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Haller, R.; Busser, U. 1976: Synthesis and configurational assignment of 1-(9'-fluorenyl)-ethylamine. Archiv der Pharmazie 309(6): 512-520

Daoust, H.; St-Pierre, S. 1976: Synthesis and conformation of sequential polypeptides containing epsilon-benzyloxycarbonyl-lysine and benzyl esters of aspartic and glutamic acids. Journal of the Chemical Society. Perkin Transactions 13: 1453-1457

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Helbecque, N.; Bernier, J.L.; Hénichart, J.P.; Martinage, A.; Sautière, P. 1987: Synthesis and conformation of the amino-terminal hexapeptide of histone H2B from gonads of the starfish Asterias rubens. International Journal of Peptide and Protein Research 30(5): 689-694

Ishii, H.; Nadaoka, O.; Mimura, Y.; Inoue, Y.; Chûjô, R. 1989: Synthesis and conformational analysis of Aib-containing peptide modelling for N-glycosylation site in N-glycoprotein. International Journal of Biological Macromolecules 11(6): 329-334

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Helander, A.; Kenne, L.; Oscarson, S.; Peters, T.; Brisson, J.R. 1992: Synthesis and conformational and NMR studies of alpha-D-mannopyranosyl and alpha-D-mannopyranosyl-(1----2)-alpha-D-mannopyranosyl linked to L-serine and L-threonine. Carbohydrate Research 230(2): 299-318

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Polinsky, A.; Cooney, M.G.; Toy-Palmer, A.; Osapay, G.; Goodman, M. 1992: Synthesis and conformational properties of the lanthionine-bridged opioid peptide [D-AlaL2,AlaL5]enkephalin as determined by NMR and computer simulations. Journal of Medicinal Chemistry 35(22): 4185-4194

Mapelli, C.; Van Halbeek, H.; Stammer, C.H. 1990: Synthesis and conformational studies by 1H- and 13C-NMR spectroscopy of a novel, sterically constrained analogue of thyrotropin-releasing hormone. Biopolymers 29(2): 407-422

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Laczkó, I.; Hollósi, M.; Urge, L.; Ugen, K.E.; Weiner, D.B.; Mantsch, H.H.; Thurin, J.; Otvös, L. 1992: Synthesis and conformational studies of N-glycosylated analogues of the HIV-1 principal neutralizing determinant. Biochemistry 31(17): 4282-4288

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D'Alagni, M.; Manigrasso, M. 1988: Synthesis and conformational study in solution and in solid state of oligopeptides containing L-leucine and glycine. International Journal of Peptide and Protein Research 32(3): 230-240

Vander Elst, P.; van den Berg, E.; Pepermans, H.; vander Auwera, L.; Zeeuws, R.; Tourwe, D.; van Binst, G. 1987: Synthesis and conformational study of a cyclic hexapeptide analogue of somatostatin: cyclo(Phe-D-Trp-Lys-Thr-o-AMPA). International Journal of Peptide and Protein Research 29(3): 318-330

Yamamoto, H.; Hayakawa, T. 1977: Synthesis and conformational study of poly (O,O'-dicarbobenzoxy-L-beta-3,4-dihydroxyphenyl-alpha-alanine). Biopolymers 16(7): 1593-1607

Katakai, R.; Oya, M.; Iwakura, Y. 1975: Synthesis and conformational study of sequential polypeptides, (L-ala-L-val-gly)n and (L-val-L-ala-gly)n. Biopolymers 14(7): 1315-1326

Vander Elst, P.; Elseviers, M.; De Cock, E.; Van Marsenille, M.; Tourwé, D.; Van Binst, G. 1986: Synthesis and conformational study of two L-prolyl-L-leucyl-glycinamide analogues with a reduced peptide bond. International Journal of Peptide and Protein Research 27(6): 633-642

Vander Elst, P.; Gondol, D.; Wynants, C.; Tourwé, D.; van Binst, G. 1987: Synthesis and conformational study of two cyclic analogues of somatostatin containing an AMPA-spacer unit. International Journal of Peptide and Protein Research 29(3): 331-346

Calissano, P.; Volontè, C.; Biocca, S.; Cattaneo, A. 1985: Synthesis and content of a DNA-binding protein with lactic dehydrogenase activity are reduced by nerve growth factor in the neoplastic cell line PC12. Experimental Cell Research 161(1): 117-129

Radominska-Pyrek, A.; Dabrowiecki, Z.; Horrocks, L.A. 1979: Synthesis and content of ether-linked glycerophospholipids in the harderian gland of rabbits. Biochimica et Biophysica Acta 574(2): 248-257

Lellouche, J.P.; Aubert, F.; Beaucourt, J.P.; Rechencq, E.; Niel, G.; Girard, J.P.; Rossi, J.C.; Boucard, M. 1989: Synthesis and contractile activity of new acetylenic and allenic analogues of leukotrienes C4 and D4: importance of the Z-11,12 double bond. Prostaglandins 37(1): 93-103

Niel, N.; Rechencq, E.; Muller, A.; Vidal, J.P.; Escale, R.; Durand, T.; Girard, J.P.; Rossi, J.C.; Bonne, C. 1992: Synthesis and contractile activity of new pseudopeptido and thioaromatic analogues of leukotriene D4. Prostaglandins 43(1): 45-54

Schwab, C.; Hetru, C. 1991: Synthesis and conversion study of a radiolabeled putative ecdysone precursor, 5 beta-cholest-7-ene-3 beta,6 alpha,14 alpha-triol in Locusta migratoria prothoracic glands. Steroids 56(6): 316-319

Povstianoĭ, M.V.; Akimov, A.V.; Kochergin, P.M. 1975: Synthesis and conversions of 8-bromtheophylline 7-hydrazidoacetic acid. Farmatsevtychnyi Zhurnal 2: 32-35

Bohlin, L.; Ali, Y.; Iskander, G.M. 1975: Synthesis and convulsant effects of 2- and 3-substituted strychnine derivatives. Acta Pharmaceutica Suecica 12(5-6): 461-466

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De Zwart, M.A.; van der Goot, H.; Timmerman, H. 1989: Synthesis and copper-dependent antimycoplasmal activity of 1-amino-3-(2-pyridyl)isoquinoline derivatives. 2. Amidines. Journal of Medicinal Chemistry 32(2): 487-493

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Sakoda, R.; Matsumoto, H.; Seto, K. 1992: Synthesis and crystal structure of optically active 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dim ethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate (NZ-105). Chemical and Pharmaceutical Bulletin 40(9): 2377-2381

Stroup, A.N.; Cole, L.B.; Dhingra, M.M.; Gierasch, L.M. 1990: Synthesis and crystal structures of Boc-L-Asn-L-Pro-OBzl.CH3OH and dehydration side product, Boc-beta-cyano-L-alanine-L-Pro-OBzl. International Journal of Peptide and Protein Research 36(6): 531-537

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Reisch, J.; Dziemba, P. 1991: Synthesis and cytostatic actions of 10- and 11-nitronoracronycins, molecular variations of cytostatically active acronycine. Archiv der Pharmazie 324(2): 67-71

Béres, J.; Bentrude, W.G.; Otvös, L.; Balzarini, J.; De Clercq, E. 1989: Synthesis and cytostatic and antiviral activities of 1-beta-D-ribofuranosyl-5-alkylcytosine (5-alkylcytidine) cyclic 3',5'-monophosphates. Journal of Medicinal Chemistry 32(1): 224-228

Kostka, K.; Porada, M. 1992: Synthesis and cytostatic effect of 2-phenyl-3-alkyl(aryl)-2,3-dihydro-1,3,2(lambda-5)- benzoxazaphosphorine-4-one derivatives. Archiv der Pharmazie 325(6): 325-328

Preobrazhenskaya, M.N.; Bakina, E.V.; Povarov, L.S.; Lazhko, E.I.; Aleksandrova, L.G.; Balzarini, J.; De Clercq, E. 1991: Synthesis and cytostatic properties of daunorubicin derivatives, containing N-phenylthiourea or N-ethylthiourea moieties in the 3'-position. Journal of Antibiotics 44(2): 192-199

Goya, P.; Martínez, A. 1988: Synthesis and cytostatic screening of an SO2 analogue of doridosine. Archiv der Pharmazie 321(2): 99-101

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Krohn, K.; Heins, H.; Wielckens, K. 1992: Synthesis and cytotoxic activity of C-glycosidic nicotinamide riboside analogues. Journal of Medicinal Chemistry 35(3): 511-517

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Grancharov, K.C.; Koch, M.; Volm, M.; Kolar, G.F. 1988: Synthesis and cytotoxic effects of hydroxymethyl-3-pyridyl- and 2-chloro-5-pyridyltriazene derivatives. Cancer Letters 41(3): 271-279

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Mascagna, D.; Ghanem, G.; Morandini, R.; d'Ischia, M.; Misuraca, G.; Lejeune, F.; Prota, G. 1992: Synthesis and cytotoxic properties of new N-substituted 4-aminophenol derivatives with a potential as antimelanoma agents. Melanoma Research 2(1): 25-32

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Kazimierczuk, Z.; Vilpo, J.; Hildebrand, C.; Wright, G. 1990: Synthesis and cytotoxicity of deoxyadenosine analogues: isomer distribution in the sodium salt glycosylation of 2,6-disubstituted purines. Journal of Medicinal Chemistry 33(6): 1683-1687

Aghil, O.; Bibby, M.C.; Carrington, S.J.; Double, J.; Douglas, K.T.; Phillips, R.M.; Shing, T.K. 1992: Synthesis and cytotoxicity of shikimate analogues. Structure:activity studies based on 1-crotonyloxymethyl-3R,4R,5R-trihydroxycyclohex-2-enone. Anti-Cancer Drug Design 7(1): 67-82

Kawasaki, A.M.; Wotring, L.L.; Townsend, L.B. 1990: Synthesis and cytotoxicity studies of 8-amino-6-methyl-2-beta-D-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthyle ne (7-aza-TCN) and the corresponding 2'-deoxy- and arabinonucleoside analogues. Journal of Medicinal Chemistry 33(12): 3170-3176

Steward, A.R.; Wrighton, S.A.; Pasco, D.S.; Fagan, J.B.; Li, D.; Guzelian, P.S. 1985: Synthesis and degradation of 3-methylcholanthrene-inducible cytochromes P-450 and their mRNAs in primary monolayer cultures of adult rat hepatocytes. Archives of Biochemistry and Biophysics 241(2): 494-508

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Tanaka, K.; Min, K.; Onosaka, S.; Fukuhara, C. 1987: Synthesis and degradation of erythrocyte metallothionein in cadmium-administered mice. EXPERIENTIA. Supplementum 52: 525-532

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Cousins, R.J. 1979: Synthesis and degradation of liver metallothionein. EXPERIENTIA. Supplementum 34: 293-301

Sanford, C.F.; Griffin, E.E.; Wildenthal, K. 1978: Synthesis and degradation of myocardial protein during the development and regression of thyroxine-induced cardiac hypertrophy in rats. Circulation Research 43(5): 688-694

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Biekmann, S.; Feierabend, J. 1985: Synthesis and degradation of unassembled polypeptides of the coupling factor of photophosphorylation CF1 in 70S ribosome-deficient rye leaves. European Journal of Biochemistry 152(3): 529-535

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Gavin, J.A.; Williamson, J.H. 1976: Synthesis and deposition of yolk protein in adult Drosophila melanogaster. Journal of Insect Physiology 22(11): 1457-1464

Dudycz, L.; Shugar, D.; Clercq, E.D.; Descamps, J. 1977: Synthesis and determination of antiviral activity of the 2'(3')-O-methyl derivatives of ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide). Journal of Medicinal Chemistry 20(10): 1354-1356

Ubuka, T. 1988: Synthesis and determination of glutathione derivatives. Tanpakushitsu Kakusan Koso. Protein Nucleic Acid Enzyme 33(9): 1383-1391

Gessner, W.; Brossi, A.; Shen, R.; Abell, C.W. 1985: Synthesis and dihydropteridine reductase inhibitory effects of potential metabolites of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Journal of Medicinal Chemistry 28(3): 311-317

Poliakova, T.I. 1986: Synthesis and discharge of secretions in the pancreas of the white rat in the presence of excessive hydrocortisone. Arkhiv Anatomii Gistologii i Embriologii 90(1): 65-69

Mestelan, G.; Crouzel, C.; Comar, D. 1977: Synthesis and distribution kinetics in animals of [alpha-11C] 3,4-dimethoxyphenethylamine. International Journal of Nuclear Medicine and Biology 4(3-4): 185-193

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Iwakura, Y.; Nozaki, M. 1988: Synthesis and distribution of carbohydrate chains in cleavage-stage mouse embryos carrying the t12 lethal mutation. Developmental Biology 128(2): 474-476

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Mazurenko, N.N.; Kogan, E.A.; Sukhova, N.M.; Zborovskaia, I.B. 1991: Synthesis and distribution of oncoproteins in tumor tissue. Voprosy Meditsinskoi Khimii 37(6): 53-59

Paff, M.T.; Fernandes, D.J. 1990: Synthesis and distribution of primer RNA in nuclei of CCRF-CEM leukemia cells. Biochemistry 29(14): 3442-3450

Inui, T.; Hagiwara, K.; Nakajima, K.; Kimura, T.; Nakajima, T.; Sakakibara, S. 1992: Synthesis and disulfide structure determination of agelenin: identification of the carboxy-terminus as an amide form. Peptide Research 5(3): 140-144

Kumagaye, S.; Kuroda, H.; Nakajima, K.; Watanabe, T.X.; Kimura, T.; Masaki, T.; Sakakibara, S. 1988: Synthesis and disulfide structure determination of porcine endothelin: an endothelium-derived vasoconstricting peptide. International Journal of Peptide and Protein Research 32(6): 519-526

Brzozowski, Z.; Kamiński, Z.; Angielski, S. 1979: Synthesis and diuretic properties of various 1-phenyl-3-(3,5,5-trimethyl-2-pyrazoline-1-carboimidoyl)-guanidine derivatives. Acta Poloniae Pharmaceutica 36(6): 645-650

Gao, Y.; Zong, R.; Campbell, A.; Kula, N.S.; Baldessarini, R.J.; Neumeyer, J.L. 1988: Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine. Journal of Medicinal Chemistry 31(7): 1392-1396

DeWald, H.A.; Heffner, T.G.; Jaen, J.C.; Lustgarten, D.M.; McPhail, A.T.; Meltzer, L.T.; Pugsley, T.A.; Wise, L.D. 1990: Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. Journal of Medicinal Chemistry 33(1): 445-450

Kelly, T.R.; Howard, H.R.; Koe, B.K.; Sarges, R. 1985: Synthesis and dopamine autoreceptor activity of a 5-(methylmercapto)methyl-substituted derivative of (+/-)-3-PPP (3-(3-hydroxyphenyl)-1-n-propylpiperidine). Journal of Medicinal Chemistry 28(9): 1368-1371

Claudi, F.; Cardellini, M.; Cingolani, G.M.; Piergentili, A.; Peruzzi, G.; Balduini, W. 1990: Synthesis and dopamine receptor affinities of 2-(4-fluoro-3- hydroxyphenyl)ethylamine and N-substituted derivatives. Journal of Medicinal Chemistry 33(9): 2408-2412

Claudi, F.; Cingolani, G.M.; Giorgioni, G.; Cattabeni, F.; Cimino, M.; Di Luca, M. 1989: Synthesis and dopamine receptor affinities of 6-amino-5,6,7,8-tetrahydroquinoline derivatives. Drug Design and Delivery 4(4): 279-287

Gao, Y.G.; Baldessarini, R.J.; Kula, N.S.; Neumeyer, J.L. 1990: Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues. Journal of Medicinal Chemistry 33(6): 1800-1805

Neumeyer, J.L.; Gao, Y.G.; Kula, N.S.; Baldessarini, R.J. 1990: Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist. Journal of Medicinal Chemistry 33(12): 3122-3124

Cardellini, M.; Cingolani, G.M.; Claudi, F.; Perlini, V.; Balduini, W.; Cattabeni, F. 1988: Synthesis and dopamine receptors binding affinity of 2-(3-fluoro-4-hydroxyphenyl)ethylamine and its N-alkyl derivatives. Il Farmaco; Edizione Scientifica 43(1): 49-59

McDermed, J.D.; McKenzie, G.M.; Freeman, H.S. 1976: Synthesis and dopaminergic activity of (+/-)-, (+)-, and (-)-2-dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene. Journal of Medicinal Chemistry 19(4): 547-549

Cannon, J.G.; Dushin, R.G.; Long, J.P.; Ilhan, M.; Jones, N.D.; Swartzendruber, J.K. 1985: Synthesis and dopaminergic activity of (R)- and (S)-4-hydroxy-2-(di-n-propylamino)indan. Journal of Medicinal Chemistry 28(4): 515-518

Craig, J.C.; Torkelson, S.M.; Findell, P.R.; Weiner, R.I. 1989: Synthesis and dopaminergic activity of 2-substituted octahydrobenzo[f]quinolines. Journal of Medicinal Chemistry 32(5): 961-968

DeNinno, M.P.; Schoenleber, R.; Perner, R.J.; Lijewski, L.; Asin, K.E.; Britton, D.R.; MacKenzie, R.; Kebabian, J.W. 1991: Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. Journal of Medicinal Chemistry 34(8): 2561-2569

Weinstock, J.; Gaitanopoulos, D.E.; Oh, H.J.; Pfeiffer, F.R.; Karash, C.B.; Venslavsky, J.W.; Sarau, H.M.; Flaim, K.E.; Hieble, J.P.; Kaiser, C. 1986: Synthesis and dopaminergic activity of some halogenated mono- and dihydroxylated 2-aminotetralins. Journal of Medicinal Chemistry 29(9): 1615-1627

Claudi, F.; Cristalli, G.; Martelli, S.; Perlini, V.; Massi, M.; Venturi, F. 1986: Synthesis and dopaminergic activity of trans-6-methyl-7a,8,9,10,11,11a-hexahydro-7H-pyrrolo[3,2,1-gh]- 4,7-phenanthroline and trans-1,2,3,4,4a,5,6,10b-octahydro-4,7-phenanthroline derivatives. Journal of Medicinal Chemistry 29(6): 1061-1065

Ladd, D.L.; Weinstock, J.; Wise, M.; Gessner, G.W.; Sawyer, J.L.; Flaim, K.E. 1986: Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes. Journal of Medicinal Chemistry 29(10): 1904-1912

Brown, D.M.; Lin, P.K. 1991: Synthesis and duplex stability of oligonucleotides containing adenine-guanine analogues. Carbohydrate Research 216: 129-139

Lin, P.K.; Brown, D.M. 1989: Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues. Nucleic Acids Research 17(24): 10373-10383

Reissmann, S.; Paegelow, I.; Filatova, M.P.; Krit, N.A.; Arold, H. 1985: Synthesis and effect of affinity-labeled analogs and partial sequences of the bradykinin potentiating nonapeptide BPP9 alpha (teprotide). Die Pharmazie 40(5): 314-317

Iuchi, K.; Nitta, M.; Ito, K.; Shimohara, K.; Tsukamoto, G. 1988: Synthesis and effect on gastric secretion of several di- or tripeptides related to proglumide. Chemical and Pharmaceutical Bulletin 36(10): 3961-3966

Abiko, T.; Kumikawa, M.; Sekino, H. 1979: Synthesis and effects of two peptide fragments of thymopoietin Ii on E-rosette forming cells in the uremic state. Chemical and Pharmaceutical Bulletin 27(9): 2233-2237

Whiteley, J.M.; Webber, S.; Kerwar, S.S. 1986: Synthesis and efficient isolation procedure for gamma-linked fluorescein methotrexate. Preparative Biochemistry 16(2): 143-154

Dodd, N.J.; Harcus, R.G.; Preston, P.N. 1976: Synthesis and electron spin resonance study of spin-labelled compounds related to tumour-growth inhibitory nitroarylaziridines. Zeitschrift für Naturforschung. Section C Biosciences 31(5-6): 328-330

Lane, R.W.; Gillum, W.O.; Laskowski, E.J.; Holm, R.H.; Frankel, R.B.; Papaefthymiou, G.C. 1977: Synthesis and electronic properties of the tetranuclear trianions [Fe4S4(SR)4]3-, analogues of the 4-Fe active sites of reduced ferredoxins. Journal of the American Chemical Society 99(7): 2350-2352

Mangold, J.B.; Lavelle, J.M. 1986: Synthesis and enantioselective mutagenicity of azidoalanine in Salmonella typhimurium. Chemico-Biological Interactions 60(2): 183-190

Schlicht, H.J.; Radziwill, G.; Schaller, H. 1989: Synthesis and encapsidation of duck hepatitis B virus reverse transcriptase do not require formation of core-polymerase fusion proteins. Cell 56(1): 85-92

Hanson, R.F.; Pries, J.M. 1977: Synthesis and enterohepatic circulation of bile salts. Gastroenterology 73(3): 611-618

Marumoto, R.; Yoshioka, Y.; Naka, T.; Shima, S.; Miyashita, O.; Maki, Y.; Suzuki, T.; Honjo, M. 1979: Synthesis and enzymatic activity of adenosine 3',5'-cyclic phosphate analogs. Chemical and Pharmaceutical Bulletin 27(3): 990-1003

Van Batenburg, O.D.; Kerling, K.E.; Havinga, E. 1976: Synthesis and enzymatic activity of an RNase S' analogue in which the 4-imidazolylglycyl residue takes the position and the role of histidine-12. Febs Letters 68(2): 228-230

Sági, G.; Szũcs, K.; Vereb, G.; Otvös, L. 1992: Synthesis and enzymatic activity of some new purine ring system analogues of adenosine 3',5'-cyclic monophosphate. Journal of Medicinal Chemistry 35(24): 4549-4556

Yagen, B.; Levy, S.; Mechoulam, R.; Ben-Zvi, Z. 1977: Synthesis and enzymatic formation of a C-glucuronide of delta6-tetrahydrocannabinol. Journal of the American Chemical Society 99(19): 6444-6446

Agarwal, K.L.; Riftina, F. 1979: Synthesis and enzymatic properties of deoxyribooligonucleotides containing methyl and phenylphosphonate linkages. Nucleic Acids Research 6(9): 3009-3024

Ogawa, S.; Nakamura, Y. 1992: Synthesis and enzyme-inhibitory activity of methyl acarviosin analogues having the alpha-manno configuration. Carbohydrate Research 226(1): 79-89

Christensen, L.F.; Meyer, R.B.; Miller, J.P.; Simon, L.N.; Robins, R.K. 1975: Synthesis and enzymic activity of 8-acyl and 8-alkyl derivatives of guanosine 3, 5-cyclic phosphate. Biochemistry 14(7): 1490-1496

Vafina, M.G.; Molodtsov, N.V.; Fedoreeva, L.I. 1975: Synthesis and enzymic hydrolysis of some p-nitrophenyl 2-aroylamino-2-deoxy-beta-D-glucopyranosides. Carbohydrate Research 44(1): 142-149

Petrović, J.A.; Pejanović, V.M.; Miljković, D.A.; Hranisavljević, J.T. 1990: Synthesis and estrogen activity screening of some new D-secoestrone derivatives. Steroids 55(6): 276-278

McCague, R.; Kuroda, R.; Leclercq, G.; Stoessel, S. 1986: Synthesis and estrogen receptor binding of 6,7-dihydro-8-phenyl-9-[4-[2-(dimethylamino)ethoxy] phenyl]-5H-benzocycloheptene, a nonisomerizable analogue of tamoxifen. X-ray crystallographic studies. Journal of Medicinal Chemistry 29(10): 2053-2059

Hanson, R.N.; Napolitano, E.; Fiaschi, R. 1990: Synthesis and estrogen receptor binding of novel 11 beta-substituted estra-1,3,5(10)-triene-3,17 beta-diols. Journal of Medicinal Chemistry 33(12): 3155-3160

Ruenitz, P.C.; Bagley, J.R.; Nanavati, N.T. 1988: Synthesis and estrogen receptor selectivity of 1,1-bis(4-hydroxyphenyl)-2-(p-halophenyl)ethylenes. Journal of Medicinal Chemistry 31(7): 1471-1475

Kanojia, R.M.; Allen, G.O.; Killinger, J.M.; McGuire, J.L. 1979: Synthesis and estrogenic properties of 17-epi-ethynylestradiol and its ether derivatives epimestranol and epiquinestrol. Journal of Medicinal Chemistry 22(12): 1538-1541

Lefebvre, Y.; Marshall, D.J.; Revesz, C. 1975: Synthesis and estrogenic properties of 7 alpha,8 alpha-epoxy- and 7 alpha, 8 alpha-methyleneestradiols. Journal of Medicinal Chemistry 18(2): 220-222

Glamkowski, E.J.; Reitano, P.A. 1979: Synthesis and evaluation for diuretic activity of 1-substituted 6-chloro-5-sulfamylindolines. Journal of Medicinal Chemistry 22(1): 106-109

AboulWafa, O.M.; Mohy el-Din, M.M.; Mohsen, A.; Omar, M.E. 1992: Synthesis and evaluation for uterotrophic and antiimplantation activities of 2-substituted estradiol derivatives. Steroids 57(4): 199-204

Saxty, B.A.; Novelli, R.; Dolle, R.E.; Kruse, L.I.; Reid, D.G.; Camilleri, P.; Wells, T.N. 1991: Synthesis and evaluation of (+) and (-)-2,2-difluorocitrate as inhibitors of rat-liver ATP-citrate lyase and porcine-heart aconitase. European Journal of Biochemistry 202(3): 889-896

Hanson, R.N.; Franke, L.A.; Kaplan, M.L. 1989: Synthesis and evaluation of (17 alpha,20E)21-[125I]iodo-11-substituted-19-norpregna-1,3,5(10), 20-tetraene-3,17 beta-diols: the influence of 11-stereochemistry on tissue distribution of radioiodinated estrogens. International Journal of Radiation Applications and Instrumentation. Part B Nuclear Medicine and Biology 16(1): 3-9

Tsai, B.S.; Peach, M.J.; Khosla, M.C.; Bumpus, F.M. 1975: Synthesis and evaluation of (Des-Asp1)angiotensin i as a precursor for (Des-Asp1)angiotensin Ii ("Angiotensin III"). Journal of Medicinal Chemistry 18(12): 1180-1183

Shyam, K.; Penketh, P.G.; Divo, A.A.; Loomis, R.H.; Patton, C.L.; Sartorelli, A.C. 1990: Synthesis and evaluation of 1,2,2-tris(sulfonyl)hydrazines as antineoplastic and trypanocidal agents. Journal of Medicinal Chemistry 33(8): 2259-2264

Fliedner, L.J.; Myers, M.J.; Schor, J.M.; Pachter, I.J. 1976: Synthesis and evaluation of 1,omega-diaryl-l,omega-alkanediamines related to the fibrinolytic bis(tetrahydroisoquinolines) and bis(benzylamines). Journal of Medicinal Chemistry 19(2): 202-208

Hrubiec, R.T.; Shyam, K.; Cosby, L.A.; Sartorelli, A.C. 1986: Synthesis and evaluation of 1-(arylsulfonyl)-2-[(methoxycarbonyl)sulfenyl]-1-methylhydrazines++ + as antineoplastic agents. Journal of Medicinal Chemistry 29(9): 1777-1779

Dimmock, J.R.; Nyathi, C.B.; Smith, P.J. 1978: Synthesis and evaluation of 1-(hydroxyphenyl)-1-nonen-3-ones and related compounds for antineoplastic and antimicrobial activities. Journal of Pharmaceutical Sciences 67(11): 1543-1546

Hashimoto, K.; Inoue, O.; Suzuki, K.; Yamasaki, T.; Kojima, M. 1989: Synthesis and evaluation of 11C-PK 11195 for in vivo study of peripheral-type benzodiazepine receptors using positron emission tomography. Annals of Nuclear Medicine 3(2): 63-71

Nichols, D.E.; Hoffman, A.J.; Oberlender, R.A.; Riggs, R.M. 1986: Synthesis and evaluation of 2,3-dihydrobenzofuran analogues of the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane: drug discrimination studies in rats. Journal of Medicinal Chemistry 29(2): 302-304

Hahn, K.M.; Hastie, S.B.; Sundberg, R.J. 1992: Synthesis and evaluation of 2-diazo-3,3,3-trifluopropanoyl derivatives of colchicine and podophyllotoxin as photoaffinity labels: reactivity, photochemistry, and tubulin binding. Photochemistry and Photobiology 55(1): 17-27

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