Synthetic cephalosporins. VI. Synthesis and antibacterial activity of 7-[ (Z) -2- (2-aminothiazol-4-yl) -2- (1-carboxy-1-methyl) ethoxyiminoacetamido]- 3- (3-hydroxy-4-pyridon-1-yl) methyl-3-cephem-4-carboxylic acid and related compounds
Sakagami, K.; Iwamatsu, K.; Atsumi, K.; Hatanaka, M.
Chemical and Pharmaceutical Bulletin 38(8): 2271-2273
1990
ISSN/ISBN: 0009-2363 PMID: 2126226 DOI: 10.1248/cpb.38.2271
Accession: 041524145
Synthesis and antibacterial activity of 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-1-methyl)ethoxyimin oacetamido]- 3-(3-hydroxy-4-pyridon-1-yl)-3-cephem-4-carboxylic acid (12) and its related compounds are described. Compound 12 exhibited excellent antibacterial activity against gram-negative bacteria, and its anti-pseudomonal activity was ten to fifteen times greater than that of ceftazidime.
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