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The Drosophila Go alpha-like G protein gene produces multiple transcripts and is expressed in the nervous system and in ovaries


The Drosophila Go alpha-like G protein gene produces multiple transcripts and is expressed in the nervous system and in ovaries



Journal of Biological Chemistry 264(31): 18544-18551



ISSN/ISBN: 0021-9258

PMID: 2509463

Drosophila melanogaster cDNA clones coding for the alpha subunit of a Go-like G protein have been isolated. The sequence of two cDNA clones shows there is alternative splicing in the 5'-coding region which, on conceptual translation, would give rise to two proteins with slightly different amino termini. A partial genomic clone indicates there are four introns in the carboxyl-terminal half of the clone. Two transcripts, 3.8 and 5.3 kilobases long, are expressed at a high level in the heads of adult flies and also in larvae, pupae, and embryos. Hybridization of the cDNA probes to sections of adult flies indicates the RNA is present predominantly in nervous tissue (in the cortex of the brain and the thoracic ganglion); it is also expressed in the ovaries. Transcripts corresponding to both cDNAs are present in the central nervous system, but only one of them is found in detectable levels in the ovaries. The gene maps to 47A on the Drosophila second chromosome.

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Accession: 041557282

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