The L1 family (KpnI family) sequence near the 3' end of human beta-globin gene may have been derived from an active L1 sequence

Fujita, A.; Hattori, M.; Takenaka, O.; Sakaki, Y.

Nucleic Acids Research 15(10): 4007-4020


ISSN/ISBN: 0305-1048
PMID: 3035487
DOI: 10.1093/nar/15.10.4007
Accession: 041561432

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We previously reported that some L1 family (KpnI family) members are closely associated with the Alu family sequence. To understand the details of the L1-Alu association, the structure of a L1-Alu unit downstream from the beta-globin gene was compared between human and primates. The results revealed that the L1-Alu-associated sequence was formed by the insertion of the L1 sequence, T beta G41, into the 3' poly A tract of the preexisting Alu family sequence. It was estimated that the T beta G41 sequence was inserted after the divergence of Old World monkeys and hominoids and before the divergence of orang-utan and common ancestor of other higher hominoids. From the calculation of the mutation rates of L1 sequences, it was suggested that the T beta G41 was derived from an active L1 sequence which was able to encode reverse transcriptase-related protein.