+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The Shy-Drager syndrome



The Shy-Drager syndrome



Fortschritte der Neurologie Psychiatrie und Ihrer Grenzgebiete 46(3): 107-143



The most prominent symptom of Shy-Drager syndrome is the asympathicotonic orthostatic (postural) hypotension, which is associated with a number of additional autonomic and neurological disturbances: disorders of micturition, sphincter disturbances, impotence, anhidrosis, hypokinesia, rigidity, pyramidal symptoms, cerebellar dysfunction and nuclear pareses due to anterior horn cell degeneration. The various disorders are not caused by ischemia or hypotension, but they represent parts of a multisystemic disease of still unknown etiology. According to different extension and neuropathological criteria it has been suggested to distinguish two types of neurogenic (idiopathic) orthostatic hypotension. Moreover, differential diagnosis of the Shy-Drager syndrome has to consider postural hypotension occuring as a symptom in some neuropathies and Parkinson's disease. Symptomatology, course, prognosis and treatment of Shy-Drager syndrome are described, as well as relevant findings of apparative investigations, pharmacological and hemodynamic tests and neuropathological findings in autopsied cases reported in the literature. This review was initiated by two clinically investigated cases of Shy-Drager syndrome.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 041566544

Download citation: RISBibTeXText

PMID: 246413


Related references

The Shy-Drager syndrome. What did Shy and Drager really describe?. Archives of Neurology 52(7): 656-657, 1995

Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and Gerhardt syndrome associated with Shy-Drager syndrome. Internal Medicine 33(12): 773-778, 1994

Syndrome of Inappropriate Secretion of Antidiuretic Hormone and Gerhardt Syndrome Associated with Shy-Drager Syndrome. Internal Medicine 33(12): 773-778, 1994

Preparation of the Drager Fabius CE and Drager Zeus anaesthetic machines for patients susceptible to malignant hyperthermia. European Journal of Anaesthesiology 29(5): 229-234, 2012

A comparison of the Drager GS vs Drager 6000 for infant ventilation. Anesthesiology 91(3A): A1311, 1999

Bilateral abductor vocal cord paralysis (Gerhardt syndrome) in the Shy-Drager syndrome. Rinsho Shinkeigaku 29(10): 1232-1236, 1989

Orthostatic hypotension associated with a cerebellar syndrome. Limits of the Shy-Drager syndrome. Revue Neurologique 126(6): 442-443, 1972

Orthostatic hypotension associated with a cerebellar syndrome the limits of shy drager syndrome. Revue Neurologique (Paris) 126(6): 442-443, 1972

Shy-Drager syndrome and the syndrome of inappropriate secretion of antidiuretic hormone. Rinsho Shinkeigaku 32(2): 177-181, 1992

A case of impending neuroleptic malignant syndrome associated with Shy-Drager syndrome. No to Shinkei 50(8): 745-749, 1998

Monoamine imbalance of the central nervous system in a case of Shy-Drager syndrome with recurrent attacks of a neuroleptic malignant syndrome. Rinsho Shinkeigaku 36(5): 696-698, 1996

Sleep apnea syndrome in a patient with Shy-Drager syndrome. Archives of Internal Medicine 138(2): 206-209, 1978

A case of Shy-Drager syndrome complicated with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and incomplete paralysis of bilateral vocal cords. Nihon Naibunpi Gakkai Zasshi 70(2): 75-84, 1994

The Shy-Dräger syndrome. Anaesthesia 35(10): 1020-1021, 1980

Shy-Drager syndrome. New England Journal of Medicine 312(6): 378-379, 1985