The combined effect of nonsteroidal anti-oestrogens and sex steroids on the growth of rat uterine adenocarcinoma cells in tissue culture

Sekiya, S.; Takamizawa, H.

British Journal of Obstetrics and Gynaecology 83(3): 183-186

1976


ISSN/ISBN: 0306-5456
PMID: 943174
DOI: 10.1111/j.1471-0528.1976.tb00806.x
Accession: 041594529

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Abstract
Nonsteroidal anti-oestrogenic drugs, tamoxifen and clomiphene citrate, at concentrations higher than 0.001 mug/ml reduced the colony forming ability of cells derived from a rat uterine adenocarcinoma in vitro. The 50 per cent inhibitory dose of these drugs was about one-hundredth of that of sex steroids. When the cells were treated with combinations of these nonsteroidal anti-oestrogenic drugs and the 50 per cent inhibitory dose (8 mug/ml) of progesterone, a synergistic effect on the inhibition of colony formation was observed. In contrast to progesterone, oestradiol-17beta (the 50 per cent inhibitory dose of which was about 16 mug/ml) suppressed additively the colony formation only in combination with low doses of anti-oestrogenic drugs.

The combined effect of nonsteroidal anti-oestrogens and sex steroids on the growth of rat uterine adenocarcinoma cells in tissue culture