EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The combined radiation and hormonal therapy of prostatic carcinoma: a conceptual analysis






Strahlentherapie und Onkologie 167(9): 523-529

The combined radiation and hormonal therapy of prostatic carcinoma: a conceptual analysis

The concept of a combination of radiotherapy and hormonal therapy for the treatment of locally advanced carcinoma of the prostate was evaluated in view of an improved success rate compared to radiotherapy alone. At present, however, radiotherapy still remains the central mode of therapy in the treatment of the local tumor. The time sequence in a combination with hormonal therapy is of importance. Antecedent hormonal treatment can reduce tumor size, thus improving local conditions for percutaneous--and especially interstitial--radiotherapy; it is indicated in patients with voiding problems. An improvement in survival rates has so far not been achieved, however, local tumor remission rates are better. With concomitant hormonal therapy, compared to radiotherapy alone, tumor progression rates are lower. It remains to be seen, whether these results can be improved by using newer pharmacological ways of androgen blockade. The application of androgen withdrawal as a secondary measure with local tumor persistence or progression after radiotherapy remains a palliative treatment of limited efficacy. Due to the heterogeneity of the available study reports and the concurrent lack of controlled, randomized trials, a conclusive evaluation of the concept of combined radio- and hormonal therapy of prostatic cancer is as yet not possible.

(PDF 0-2 workdays service: $29.90)

Accession: 041594594

PMID: 1718045



Related references

Combined hormonal and radiation therapy for prostatic carcinoma. Strahlentherapie und Onkologie 167(9): 523-529, 1991

Hormonal, radiation and combined therapy of locally advanced prostatic cancer (T3NXM0). Urologiia: 24-26, 2005

External radiation therapy of prostatic carcinoma and its relationship to hormonal therapy. Radiation Medicine 13(6): 297-300, 1995

Extended field radiation therapy vs. delayed hormonal therapy in node positive prostatic adeno carcinoma. Journal of Urology 127(5): 935-937, 1982

New hormonal therapy in prostatic carcinoma: combined treatment with an LHRH agonist and an antiandrogen. Clinical and Investigative Medicine. Medecine Clinique et Experimentale 5(4): 267-275, 1982

Neoadjuvant combined hormonal therapy and radiotherapy with external beam irradiation in prostatic carcinoma. La Radiologia Medica 93(4): 446-450, 1997

Results of treatment of prostatic carcinoma by means of transcystic prostatectomy combined with castration and hormonal therapy. Polski Przeglad Chirurgiczny 47(2a): 247-251, 1975

Glycoprotein A-80 in the human prostate: Immunolocalization in prostatic intraepithelial neoplasia, carcinoma, radiation failure, and after neoadjuvant hormonal therapy. Urology 61(1): 248-252, January, 2003

Improved early detection of recurrence in prostatic carcinoma following hormonal therapy. Combined use of palpation and fine needle aspiration cytology. Urology 36(4): 341-345, 1990

Treatment of prostatic carcinoma in clinical stage C. Comparison between radiotherapy plus hormonal therapy after progression and immediate hormonal therapy. Minerva Urologica E Nefrologica 46(2): 123-128, 1994