+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

The distribution of degenerative changes in INH neuropathy. Further evidence for focal axonal lesions

The distribution of degenerative changes in INH neuropathy. Further evidence for focal axonal lesions

Acta Neuropathologica 48(1): 1-9

Rats were given isoniazid either in a single large dose or continuously in drinking water and killed 5--105 days later. The distribution of degenerating fibres in various nerves (sensory and mixed) and in various sites along nerves and spinal roots was studied by light and electron microscopy. It was found that sensory nerves tended to be less affected than motor, and degeneration was more proximal in the latter. It was concluded that the pattern of degeneration and regeneration supported the view that the initial metabolic lesion is in the axon, rather than in the cell body.

(PDF emailed within 1 workday: $29.90)

Accession: 041611738

Download citation: RISBibTeXText

PMID: 228520

Related references

The distribution of degenerative changes in isoniazid neuropathy further evidence for focal axonal lesions. Acta Neuropathologica 48(1): 1-10, 1979

Degenerative and inflammatory lesions in sympathetic ganglia: further morphological evidence for an autonomic neuropathy in AIDS. Journal of Neuro-Aids 2(3): 67-82, 2006

Focal Defects of the Knee Articular Surface: Evidence of a Regenerative Potential Pattern in Osteochondritis Dissecans and Degenerative Lesions. Biomed Research International 2017: 9036305, 2018

Tubulomembranous lesions in p-bromophenylacetylurea neuropathy reflect local stasis of fast axonal transport: evidence from electron microscopic autoradiography. Mayo Clinic Proceedings 67(4): 341-348, 1992

Pure axonal neuropathy: nerve xenografts and clinicopathological study of a family with peripheral neuropathy, hereditary ataxia, focal necrotizing encephalopathy, and spongy degeneration of brain. Annals of Neurology 7(3): 251-261, 1980

Electron microscopy of focal neuro-axonal lesions produced by - '-iminodipropionitrile in rats. L The advanced lesions. Acta Neuropathol 4(6): 590-603, 1965

Giant axonal neuropathy: report on a case with focal fiber loss. Acta Neuropathologica 83(5): 543-546, 1992

Axonal neurofilamentous accumulations: a comparison between human and canine giant axonal neuropathy and 2,5-HD neuropathy. Neuropathology and Applied Neurobiology 19(3): 224-232, 1993

MRI reveals segmental distribution of enterovirus lesions in the central nervous system: a probable clinical evidence of retrograde axonal transport of EV-A71. Journal of Neurovirology 2019, 2019

A case of giant axonal neuropathy showing focal aggregation and hypophosphorylation of intermediate filaments. Brain & Development 20(8): 594-597, 1998

Hereditary motor and sensory neuropathy type II with axonal lesions. Journal of Neurology 235(4): 254-255, 1988

Axonal degeneration with unusual lesions of the myelin in an occupational neuropathy. Ultrastructural Pathology 30(4): 261-266, 2006

Cerebral white matter lesions in acute motor axonal neuropathy. Neurology 61(2): 272-273, 2003

Electrophysiological changes after focal brain lesions in a model of axonal sprouting. Society for Neuroscience Abstracts 25(1-2): 1513, 1999

Bilateral spinal anterior horn lesions in acute motor axonal neuropathy. Brain and Development 40(9): 830-832, 2018