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The effect of antidepressants on the reorganization of circadian mobility in normal and stressed rats after a shift in the light regimen



The effect of antidepressants on the reorganization of circadian mobility in normal and stressed rats after a shift in the light regimen



Eksperimental'naia i Klinicheskaia Farmakologiia 55(6): 3-5



Changes in the light regime caused a continuous reorganization of circadian motor rhythm with a gradual formation of a new pattern of circadian mobility. Both chronic administration of imipramine and maprotiline and pain stress-induced simulation of depression modified this process in different ways. However, when antidepressants were given, impairments in rhythm resynchronization attenuated in the stressed rats to a great extent.

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Accession: 041618366

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PMID: 1305871


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