Home
  >  
Section 42
  >  
Chapter 41,627

The effect of kainic, quinolinic and beta-kainic acids on the release of endogenous amino acids from rat brain slices

Connick, J.H.; Stone, T.W.

Biochemical Pharmacology 35(20): 3631-3635

1986

ISSN/ISBN: 0006-2952
PMID: 2876711
DOI: 10.1016/0006-2952(86)90636-2
Accession: 041626054
Download citation:  
Text
  |  
BibTeX
  |  
RIS
It has been suggested that the neurotoxic properties of quinolinic acid and kainic acid may, at least in part, involve an indirect action on nerve terminals containing glutamate. In the present study it is confirmed that kainate causes the release of endogenous glutamate from rat hippocampal slices, but that quinolinic acid does not share this activity. In addition beta-kainic acid was found to depress the potassium evoked release of endogenous glutamate at relatively high concentrations and this effect may underlie the anticonvulsant properties of this substance.

PDF emailed within 0-6 h: $19.90




Related References

Connick, J.H.; Stone, T.W. 1986: The effect of kainic acid quinolinic acid and beta kainic acid on the release of endogenous amino acids from rat brain slices Biochemical Pharmacology 35(20): 3631-3636
Ferkany, J.W.; Coyle, J.T. 1983: Kainic acid selectively stimulates the release of endogenous excitatory acidic amino acids Journal of Pharmacology and Experimental Therapeutics 225(2): 399-406
Poli, A.; Contestabile, A.; Migani, P.; Rondelli, C.; Rossi, L.; Barnabei, O. 1984: Effect of kainic acid on the release of endogenous and exogenous amino acids from synaptosome preparations Neuroscience Letters (Suppl 18): S191
Virgili, M.; Poli, A.; Contestabile, A.; Migani, P.; Barnabei, O. 1986: Synaptosomal release of newly-synthetized or recently accumulated amino acids. Differential effects of kainic acid on naturally occurring excitatory amino acids and on [d-(3)H]aspartate Neurochemistry International 9(1): 29-33
Virgili, M.; Poli, A.; Contestabile, A.; Migani, P.; Barnabei, O. 1986: Synaptosomal release of newly synthetized or recently accumulated amino acids differential effects of kainic acid on naturally occurring excitatory amino acids and on tritiated d aspartate Neurochemistry International 9(1): 29-34
Fukunishi, I.; Murakami, T.; Negi, T.; Hosokawa, K. 1990: The release of zinc and amino acids into the hippocampus by intracranial perfusion of kainic acid studies using brain microdialysis and timm staining Neurosciences 16(4): 613-622
Collingridge, G.L.; Kehl, S.J.; Loo, R.; McLennan, H. 1983: Effects of kainic and other amino acids on synaptic excitation in rat hippocampal slices: 1. Extracellular analysis Experimental Brain Research 52(2): 170-178
Cuenod, M. 1984: Depolarization induced release of endogenous sulfur containing amino acids in rat brain slices Society For Neuroscience Abstracts: 232
Racz, W.J. 1986: Release of endogenous amino acids from slices of mouse brain following methylmercury poisoning Society For Neuroscience Abstracts: 1564
Liu, J.; Cheng, J. 1995: Changes of amino acids release in rat's hippocampus during kainic acid induced epilepsy and acupuncture Zhen Ci Yan Jiu 20(3): 50-54
Umeda, Y.; Sumi, T. 1991: Changes in the release of endogenous amino acids from rat brain slices in response to in vitro experimental ischemia Japanese Journal of Pharmacology 55(Suppl 1): 352P
Umeda, Y.ri; Sumi, Takahiko 1994: Electrically stimulated release of endogenous dopamine and amino acids from rat brain slices under ischemia-like condition Japanese Journal of Pharmacology 64(Suppl 1): 231P
Geula, C.; Slevin, J.T. 1986: Effect of entorhinal kindling on potassium or kainic acid stimulated release of amino acids in rat hippocampus Society for Neuroscience Abstracts 12(1): 344
Benjamin, A.M.; Quastel, J.H. 1972: Locations of amino acids in brain slices from the rat. Tetrodotoxin-sensitive release of amino acids Biochemical Journal 128(3): 631-646
Townend, T.J.; Wetherell, J.R.; Kitchen, I.; Tattersall, J. 1996: Effects of the anticholinesterase soman on potassium-stimulated ex vivo release of -acetylcholine and endogenous amino acids in guinea pig brain slices Society for Neuroscience Abstracts 22(1-3): 1911
Butcher, S.P.; Hamberger, A. 1987: In vivo studies on the extracellular, and veratrine-releasable, pools of endogenous amino acids in the rat striatum: effects of corticostriatal deafferentation and kainic acid lesion Journal of Neurochemistry 48(3): 713-721
Makman, M.H.; Chung, H. 1994: Kainic acid receptor desensitization plays a major role in modulation of GABA release by excitatory amino acids in rat retina IOVS Investigative Ophthalmology and Visual Science 35(4): 1361
Vezzani, A.; Stasi, M.A.; Serafini, R.; De Simoni, M.G.; Fodritto, F.; Samanin, R. 1988: Modulation by sms 201 995 a synthetic analog of somatostatin st of limbic seizures induced by intrahippocampal injection of quinolinic and kainic acids in rats Society for Neuroscience Abstracts 14(1): 7
Tsai, P.S.; Cheng, J.K.; Marsala, M.; Lin, C.R.; Wen, G.H.; Yang, L.C. 2001: Intrathecal magnesium sulfate attenuates algogenic behavior and spinal amino acids release after kainic acid receptor activation in rats Neuroscience Letters 301(2): 115-118
Toggenburger, G.; Wiklund, L.; Henke, H.; Cuénod, M. 1983: Release of endogenous and accumulated exogenous amino acids from slices of normal and climbing fibre-deprived rat cerebellar slices Journal of Neurochemistry 41(6): 1606-1613