Section 42
Chapter 41,627

The effect of kainic, quinolinic and beta-kainic acids on the release of endogenous amino acids from rat brain slices

Connick, J.H.; Stone, T.W.

Biochemical Pharmacology 35(20): 3631-3635


ISSN/ISBN: 0006-2952
PMID: 2876711
DOI: 10.1016/0006-2952(86)90636-2
Accession: 041626054

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It has been suggested that the neurotoxic properties of quinolinic acid and kainic acid may, at least in part, involve an indirect action on nerve terminals containing glutamate. In the present study it is confirmed that kainate causes the release of endogenous glutamate from rat hippocampal slices, but that quinolinic acid does not share this activity. In addition beta-kainic acid was found to depress the potassium evoked release of endogenous glutamate at relatively high concentrations and this effect may underlie the anticonvulsant properties of this substance.

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