+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The effect of oral contraceptives on folate metabolism. III. Plasma clearance and urinary folate excretion



The effect of oral contraceptives on folate metabolism. III. Plasma clearance and urinary folate excretion



Journal of Laboratory and Clinical Medicine 85(2): 185-190



The effect of oral contraceptives (OCs) on folate metabolism was studied by determining plasma clearance and urinary folate excretion in normal women. Folic acid clearance was determined by Lactobacillus casei assay following an iv injection of pteroylmonoglutamic acid (PGA). Urinary folate excretion was determined in 12-hour specimens also by the above method. In 5 of the 6 women on OCs, plasma clearance of PGA was faster than in the 7 controls. The mean rise of serum folate during 1 hour was lower (p less than .02) in the OC users than in the controls. The mean serum folate of the OC group (93 subjects) was lower than that of the control group (67 subjects), and the urinary folate excretion was higher in the OC group than in the control group. It is concluded that women on OCs excrete more folate in their urine for any given level of serum or red cell folate than do control subjects.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 041628472

Download citation: RISBibTeXText

PMID: 1113011


Related references

The effect of oral contraceptives on folate metabolism part 3 plasma clearance and urinary folate excretion. Journal of Laboratory & Clinical Medicine 85(2): 185-190, 1975

Urinary excretion of folate catabolites responds to changes in folate intake more slowly than plasma folate and homocysteine concentrations and lymphocyte DNA methylation in postmenopausal women. Journal of Nutrition 130(12): 2949-2952, 2000

A Dual-Label Stable-Isotopic Protocol Is Suitable for Determination of Folate Bioavailability in Humans: Evaluation of Urinary Excretion and Plasma Folate Kinetics of Intravenous and Oral Doses of [13C5] and [2H2]Folic Acid. The Journal of Nutrition 127(12): 2321-2327, 1997

A dual-label stable-isotopic protocol is suitable for determination of folate bioavailability in humans: evaluation of urinary excretion and plasma folate kinetics of intravenous and oral doses of (13C5) and (2H2)folic acid. The Journal of Nutrition 127: 21-7, 1997

A dual-label stable-isotopic protocol is suitable for determination of folate bioavailability in humans: evaluation of urinary excretion and plasma folate kinetics of intravenous and oral doses of [13C5] and [2H2]folic acid. Journal of Nutrition 127(12): 2321-2327, 1998

Effect of oral administration of folate sources on plasma folate levels in pigs: comparison between reduced and oxidized forms of folate. Canadian Journal of Animal Science 77(3): 497-502, 1997

Kinetics of folate turnover in pregnant women (second trimester) and nonpregnant controls during folic acid supplementation: stable-isotopic labeling of plasma folate, urinary folate and folate catabolites shows subtle effects of pregnancy on turnover of folate pools. Journal of Nutrition 131(7): 1928-1937, 2001

Urinary excretion of deuterated folate following a single oral dose is a functional index of folate status. FASEB Journal 11(3): A234, 1997

Increased urinary folate excretion and decreased plasma folate levels in the rat after acute ethanol treatment. Alcoholism Clinical & Experimental Research 8(2): 172-178, 1984

Effect of oral contraceptives on intestinal folate conjugase activity and folate absorption in rats. Drug-Nutrient Interactions 2(1): 1-6, 1983

Dietary folate intake, blood folate status, and urinary folate catabolite excretion in Korean women of childbearing age. Journal of Nutritional Science and Vitaminology 54(4): 291-297, 2008

Urinary excretion of (2H4)folate by nonpregnant women following a single oral dose of (2H4)folic acid is a functional index of folate nutritional status. The Journal of Nutrition 128(11): 07-12, 1998

Urinary excretion of [2H4]folate by nonpregnant women following a single oral dose of [2H4]folic acid is a functional index of folate nutritional status. Journal of Nutrition 128(11): 1907-1912, 1998

Effect of orange juice, folic acid, and oral contraceptives on serum folate in women taking a folate-restricted diet. Journal of the American College of Nutrition 2(3): 221-230, 1983

The effect of oral contraceptives on folate metabolism. American Journal of Obstetrics and Gynecology 111(6): 782-791, 1971