The familial nature of multiple sclerosis: age-corrected empiric recurrence risks for children and siblings of patients

Sadovnick, A.D.; Baird, P.A.

Neurology 38(6): 990-991


ISSN/ISBN: 0028-3878
PMID: 3368082
DOI: 10.1212/wnl.38.6.990
Accession: 041651842

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Increasingly, MS patients ask neurologists about the risk that their close relatives will also develop MS. We calculated age-adjusted empiric recurrence risks from data on 815 index cases and over 3,000 of their siblings and children. In general, the risk for these relatives to develop MS is 3 to 5%, which is 30 to 50 times the 0.1% rate for the general population.