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The genetic effects of the photochemical reaction products of propylene plus NO2 on cultured Chinese hamster cells exposed in vitro

Shiraishi, F.; Bandow, H.

Journal of Toxicology and Environmental Health 15(3-4): 531-538

1985

ISSN/ISBN: 0098-4108
PMID: 4032499
DOI: 10.1080/15287398509530680
Accession: 041658569
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A study was made on the genetic effects of the photochemical reaction products of propylene plus NO2 on cultured Chinese hamster V79 cells with the use of sister chromatid exchanges (SCE). The photochemical reaction products of propylene plus NO2 were produced by photochemical reaction of a propylene-NO2/dry air system in a photochemical smog chamber and then were exposed to cell cultures for 2 h. SCEs were induced at all concentrations of the photochemical reaction products employed in the present study, the frequency of SCEs being two or three times higher than that of the controls. The genetic effects of NO2 and ozone (O3) were also studied and compared with those of the photochemical reaction products of propylene plus NO2. NO2 and O3 both induced SCEs in V79 cells, but their effects were weaker than those induced by the photochemical reaction products of propylene plus NO2. It was ascertained that the photochemical reaction of the propylene-NO2/dry air system produced much stronger genotoxic factors than the reactants.

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Related References

Shiraishi, F.; Bandow, H. 1985: The genetic effects of the photochemical reaction products of propylene plus nitrogen dioxide on cultured chinese hamster cells exposed in vitro Journal of Toxicology and Environmental Health 15(3-4): 531-538
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