The hemolytic activity of citral--II. Glutathione depletion in citral treated erythrocytes

Segal, R.; Milo-Goldzweig, I.

Biochemical Pharmacology 34(23): 4117-4119

1985


ISSN/ISBN: 0006-2952
PMID: 4062979
DOI: 10.1016/0006-2952(85)90203-5
Accession: 041662016

Download citation:  
Text
  |  
BibTeX
  |  
RIS

Article/Abstract emailed within 0-6 h
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Abstract
The role of glutathione in citral induced hemolysis was investigated. The concentration of intracellular glutathione diminished in citral treated erythrocytes. GSH disappeared before hemolysis started. Glucose inhibited citral induced hemolysis and restored the depleted cellular stores of GSH. The results presented confirm the previous suggestion that a free radical-peroxide mechanism is involved in citral induced hemolysis.