Section 42
Chapter 41,665

The human gene encoding insulin-like growth factor i is located on chromosome 12

Höppener, J.W.; de Pagter-Holthuizen, P.; Geurts van Kessel, A.H.; Jansen, M.; Kittur, S.D.; Antonarakis, S.E.; Lips, C.J.; Sussenbach, J.S.

Human Genetics 69(2): 157-160


ISSN/ISBN: 0340-6717
PMID: 2982726
DOI: 10.1007/bf00293288
Accession: 041664556

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A cDNA probe corresponding to mRNA encoding human somatomedin-C/insulin-like growth factor I (IGF-I) was used for the chromosomal assignment of the IGF-I gene. Southern-blot hybridization analysis of DNA from human-Chinese hamster somatic cell hybrids showed that the IGF-I gene is located on chromosome 12. Comparison of the chromosomal assignments of the IGF-I gene and two other members of the insulin gene family, with three c-ras oncogenes, reveals a remarkable association of the two gene families.

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