+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

The hypophysis in the regulation of androgen and oestrogen dependent enzyme activities of steroid hormone metabolism in rat liver cytosol

The hypophysis in the regulation of androgen and oestrogen dependent enzyme activities of steroid hormone metabolism in rat liver cytosol

Hoppe-Seyler's Zeitschrift für Physiologische Chemie 356(2): 127-134

ISSN/ISBN: 0018-4888

PMID: 1176083

DOI: 10.1515/bchm2.1975.356.1.127

In order to determine whether the gonadal and hypophyseal modes of regulation recently reported for the microsomal enzymes of hepatic steroid metabolism are also valid for cytoplasmic enzymes, three enzymes whose activities exhibit sex differences (male:female activity ratio shown in brackets), 5beta-reductase(1.7:1), 20alpha-hydroxysteroid dehydrogenase(5 : 1) and 17beta-hydroxysteroid dehydrogenase (4:1), as well as one enzyme whose activity shows no sex difference, 3beta-hydroxy-delta5-steroid dehydrogenase, were investigated after various interferences with the endocrine balance (gonadectomy, hypophysectomy, combination of both operations, administration of testosterone or oestradiol). From the results of this and a previous study the following statements can be made about the endocrine control of hepatic enzyme activities. Those enzymes whose activities show sex differences are either androgen or oestrogen dependent; the sex hormone acts in either an inductive or repressive manner. 1) Criteria for androgen dependency are the feminization of enzyme activity after testectomy or inhibition of testicular function by administration of oestradiol; masculinization of the enzyme activity after administration of testosterone to male or female castrates. Using these criteria the following enzymes investigated in this laboratory fall into this category: all microsomal enzymes which show sex differences in their activity (3alpha-, 3beta-, delta4-3beta, 20-hydroxysteroid dehydrogenase; cortisone alpha-reductase; steroid hydroxylases and 16alpha-hydroxylase) as well as the cytoplasmic 20alpha-hydroxysteroid dehydrogenase. Apart from the single exception of 20alpha-hydroxy-steroid dehydrogenase the presence of the hypophysis is obligatory for the androgen to be effective. The hypophysis does not only work in a permissive manner, but participates in establishing the sex specific activity levels in a manner which is antagonistic to the androgen action. 2) Criteria for oestrogen dependency are that the female animal reacts to gonadectomy, as well as to the inhibition of ovarian function after testosterone administration, by a masculinization of the enzyme activities. After administration of oestradiol, but not gonadectomy, the male animal exhibits typical female activity. Using these criteria the cytoplasmic 5beta-reductase and 17beta-hydroxysteroid dehydrogenase are oestrogen dependent. The repressive oestrogen effect observed on 17beta-hydroxysteroid dehydrogenase is antagonistic to hypophyseal action, whereas in the case of 5beta-reductase it is synergistic. 3) The activities of cytoplasmic 3beta-hydroxy-delta5-steroid dehydrogenase and microsomal 7alpha-hydroxylase show no sex differences and are not influenced by any interference with the endocrine balance.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 041665605

Download citation: RISBibTeXText

Related references

The influence of oestradiol on androgen- and oestrogen-dependent enzyme activities of hepatic steroid metabolism in rats. Endokrinologie 74(2): 153-157, 1979

The role of the hypophysis in the regulation of sex differences in the activities of enzymes involved in hepatic steroid hormone metabolism. Hoppe-Seyler's Zeitschrift für Physiologische Chemie 355(10): 1325-1331, 1974

The role of hypophysis in the regulation of sex differences in the activities of enzymes involved in hepatic steroid hormone metabolism. Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie 355(10): 1325-1331, 1974

The role of the hypophysis in the regulation of sex differences in the activities of enzymes involved in hepatic steroid hormone metabolism. Hoppe-Seyler'sZeitschriftfürPhysiologischeChemie355(10):1223, 1974

Contradictory evidence concerning the "universal" role of growth hormone in the regulation of the enzyme activities of hepatic steroid metabolism. Experimental and Clinical Endocrinology 87(2): 142-148, 1986

Studies of a thyroid hormone and androgen dependent protein in rat liver cytosol. Acta Endocrinologica 84(3): 548-558, 1977

Ontogenesis of hydroxy steroid dehydrogenase activities in rat liver age dependent development and sexual differentiation in the cytosol and the microsomal fraction. Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie 354(3): 306-311, 1973

Regulation of enzyme activities in carbohydrate metabolism dependent on the diet: various adaptive changes in the rat liver and small intestinal mucosa after feeding of fructose or glucose. Verhandlungen der Deutschen Gesellschaft für Innere Medizin 82 Pt 1: 943-945, 1976

Antagonistic action of estrogens, flutamide, and human growth hormone on androgen-induced changes in the activities of some enzymes of hepatic steroid metabolism in the rat. Endocrinology 113(3): 1043-1055, 1983

The F.S.H. content of the hypophysis of the rat as influenced by androgen; with additional data on the effect of oestrogen and of combined oestrogen-testosterone treatment. Acta Endocrinologica 24(4): 353-360, 1957

Lipid metabolism and enzyme activities in hormone-dependent and hormone-independent mammary adenocarcinoma in GR mice. Journal of the National Cancer Institute 77(1): 233-239, 1986

Effects of dietary vitamin E deficiency on steroid hormone receptors, androgen metabolism and lipid peroxidation in the male rat liver. FASEB Journal 15(5): A717, 2001

Androgen and oestrogen responsiveness of stromal cells derived from the human hyperplastic prostate: oestrogen regulation of the androgen receptor. Journal of Endocrinology 143(2): 269-277, 1994

Androgen receptor content in cytosol from non-tumoral human kidney and its relation to steroid hormone environment. Urologia Internationalis 40(6): 307-313, 1985

Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme. Archives of Biochemistry and Biophysics 263(2): 424-436, 1988