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The immunization of mice and calves with gal E mutants of Salmonella typhimurium

The immunization of mice and calves with gal E mutants of Salmonella typhimurium

Journal of Hygiene 79(1): 17-24

A galactose epimeraseless (gal E) mutant of Salmonella typhimurium was investigated in mice and calves for its suitability as a live vaccine. In mice, a very highly significant difference in the mortality rates was observed when vaccinated and non-vaccinated animals were challenged with virulent strains of S. typhimurium and S. dublin. In calves, doses of 10(6) and above of gal E mutant injected subcutaneously provided highly significant protection both in terms of mortality and prevalence of symptoms when calves were challenged orally with S. typhimurium. However, there appeared to be a relation between the vaccine and the presence of renal lesions and before gal E mutants can be recommended, further work is necessary to determine the pathogenesis of these lesions.

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Accession: 041666822

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PMID: 328767

DOI: 10.1017/s0022172400052803

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