+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The immunologic approach to analysis of malignant lymphoma. Mantle zone lymphoma of the ileocecal region

The immunologic approach to analysis of malignant lymphoma. Mantle zone lymphoma of the ileocecal region

Journal of Clinical Gastroenterology 9(5): 588-598

We studied an unusual type of lymphoma of the ileocecal region using an established protocol that combines morphologic, flow cytometric, and immunohistochemical analyses. This lymphoma grew as multiple submucosal nodules, some of which had coalesced into a mass in the terminal ileum. Histologically, the lesion resembled a lymphoma of follicular center-cell origin except for germinal centers that appeared reactive and greatly expanded follicular mantles. Flow cytometric studies showed that the lymphoma contained a monoclonal, kappa+ population of B-lymphocytes. Evaluation of sections of frozen tissue by an immunoperoxidase technique revealed that the germinal centers were polyclonal (nonneoplastic) and that the neoplastic cells were confined to the mantle zone. The additional information led to classification of the neoplasm as the mantle zone variant of intermediate lymphocytic lymphoma. This type of lymphoma may pursue a more aggressive course than a follicular lymphoma derived from the germinal center. We review our general approach to the analysis of hematolymphoid neoplasms and discuss how certain techniques may be useful adjuncts in the evaluation of these types of tumors.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 041667101

Download citation: RISBibTeXText

PMID: 3316374

DOI: 10.1097/00004836-198710000-00024

Related references

ESMO Consensus conferences: guidelines on malignant lymphoma. part 2: marginal zone lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma. Annals of Oncology 24(4): 857-877, 2013

Molecular diagnosis of malignant lymphoma: mantle cell lymphoma, anaplastic large cell lymphoma, and marginal zone B-cell lymphoma of malt. Nagoya Journal of Medical Science 68(1-2): 1-8, 2006

A histogenesis of malignant lymphoma, small cleaved cell of the B cell type and intermediate lymphocytic lymphoma (mantle zone lymphoma). An immuno- and enzymehistochemical study. Virchows Archiv. A Pathological Anatomy and Histopathology 413(3): 205-213, 1988

A histogenesis of malignant lymphoma, small cleaved cell of the B cell type and intermediate lymphocytic lymphoma (mantle zone lymphoma). Virchows Archiv 413(3): 205-213, 1988

Clinical and X-ray diagnosis of primary malignant lymphoma in the ileocecal region (an analysis of 7 cases). Zhonghua Fang she Xue Za Zhi Chinese Journal of Radiology 15(3): 196-198, 1981

A clinical analysis of two indolent lymphoma entities: mantle cell lymphoma and marginal zone lymphoma (including the mucosa-associated lymphoid tissue and monocytoid B-cell subcategories): a Southwest Oncology Group study. Blood 85(4): 1075-1082, 1995

Lymphocytic lymphoma of intermediate differentiation--mantle zone lymphoma: a distinct subtype of B-cell lymphoma. Human Pathology 18(9): 877-880, 1987

Front-line management of indolent non-Hodgkin lymphoma in Australia. Part 2: mantle cell lymphoma and marginal zone lymphoma. Internal Medicine Journal 49(9): 1070-1080, 2019

Malignant lymphoma in the ileocecal region causing intussusception. Journal of Gastroenterology 29(2): 203-207, 1994

Discordant lymphoma consisting of splenic mantle cell lymphoma and marginal zone lymphoma involving the bone marrow and peripheral blood: a case report. Journal of Medical Case Reports 5: 476, 2011

Intermediate lymphocytic mantle zone lymphoma a morphologic and immunologic study. Laboratory Investigation 56(1): 26A, 1987

A malignant lymphoma with histological features and immunophenotypic profile intermediate between EBV-positive diffuse large B-cell lymphoma and EBV-positive classical Hodgkin lymphoma in a 67-year-old female: a "gray zone" lymphoma associated with Epstein-Barr virus in the elderly. Pathology Research and Practice 208(6): 363-367, 2012

Identification of proteomic signatures of mantle cell lymphoma, small lymphocytic lymphoma, and marginal zone lymphoma biopsies by surface enhanced laser desorption/ionization-time of flight mass spectrometry. Leukemia and Lymphoma 52(4): 648-658, 2011

Mantle cell lymphoma with partial involvement of the mantle zone: an early infiltration pattern of mantle cell lymphoma?. Virchows Archiv 453(4): 407-411, 2008

Small lymphocytic lymphoma, marginal zone B-cell lymphoma, and mantle cell lymphoma exhibit distinct gene-expression profiles allowing molecular diagnosis. Blood 103(7): 2727-2737, 2004