Section 42
Chapter 41,679

The inhibitory effect of secretin and glucagon on pressure responses to cholecystokinin-pancreozymin in isolated guinea-pig stomach

Gerner, T.; Haffner, J.F.

Scandinavian Journal of Gastroenterology 13(5): 537-544


ISSN/ISBN: 0036-5521
PMID: 705248
DOI: 10.3109/00365527809181761
Accession: 041678144

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Pressure responses in guinea-pig antral and fundal pouches were investigated in vitro. Secretin and glucagon in concentrations that did not significantly alter spontaneous activity significantly reduced antral responses to cholecystokinin, but had no depressive effect on the fundal responses. The antral inhibition of CCK-PZ may be specific, since responses to acetylcholine were unaffected by secretin and glucagon. The changes produced by secretin and glucagon in the antral dose-response curve to CCK-PZ suggest that the inhibition might be of a non-competitive type.

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