+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The long-term evolution of immune deposits in passive Heymann nephritis



The long-term evolution of immune deposits in passive Heymann nephritis



Brazilian Journal of Medical and Biological Research 25(2): 149-159



1. To study the long term course of passive Heymann nephritis (PHN), 42 adult male Wistar rats were injected with rabbit anti-FX1A serum (PHN group) and 42 rats received normal rabbit serum (control group). Two animals from each group were sacrificed 2 weeks after the inoculation and 10 animals each from the control and PHN groups were sacrificed 4, 13, 25 and 53 weeks later. 2. The PHN group exhibited a significant elevation in 20-h proteinuria which lasted from the first week (control group, 9.19 +/- 0.87; PHN group, 25.3 +/- 2.66) to the 25th week (control group, 22.6 +/- 2.15; PHN group, 66.7 +/- 10.4) except for week 17. From week 29 to week 53 there was no statistical difference between the 2 groups. 3. Light microscopy showed no difference between the kidneys of PHN and control rats. Immunofluorescence microscopy in PHN rats showed granular deposition of autologous and heterologous IgG on the glomerular basement membrane (GBM), whose intensity and pattern did not change during 53 weeks of observation. 4. When examined by electron microscopy the glomeruli of PHN rats showed: a) electron-dense deposits which were initially subepithelial and homogeneous and later intramembranous, granular and often surrounded by an electron-transparent halo; b) focal thickening of the GBM at the sites of intramembranous deposits; c) effacement of podocytes located close to the deposits; d) "penetration" of the podocytes into the GBM associated with the deposits; e) presence of osmiophilic granules in the cytoplasm of the podocytes located inside the GBM similar to the granules of the deposits next to them. The association of the penetration of the podocytes into the GBM with the deposits and the presence of the osmiophilic granules inside the foot process have not been described previously in PHN.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 041686774

Download citation: RISBibTeXText

PMID: 1339511


Related references

Initial events in the formation of immune deposits id in passive heymann nephritis phn. Kidney International: 170, 1987

Quantification of immune deposits in passive heymann nephritis by double labeling immunoelectron microscopy. Japanese Journal of Clinical Electron Microscopy 24(5-6): 898-899, 1991

Lipoproteins accumulate in immune deposits and are modified by lipid peroxidation in passive Heymann nephritis. American Journal of Pathology 149(4): 1313-1320, 1996

Proteolytic enzyme treatment reduces glomerular immune deposits and proteinuria in passive Heymann nephritis. Journal of Experimental Medicine 164(6): 1973-1987, 1986

Reduction in proteinuria and glomerular immune deposits in passive heymann nephritis by proteolytic enzyme treatment. Federation Proceedings 45(4): 950, 1986

Long-Term Observation of Passive Heymann Nephritis. Nephron 41(4): 348-353, 1985

Long-term observation of passive Heymann nephritis. Nephron 41(4): 348-353, 1985

Analysis of ultrastructural immune deposits in passive heymann nephritis by double-staining methods with electron microscopy. Nephron 59(2): 244-249, 1991

Analysis of Ultrastructural Immune Deposits in Passive Heymann Nephritis by Double-Staining Methods with Electron Microscopy. Nephron 59(2): 244-249, 1991

Polyvalent antigen-antibody interactions are required for the formation of electron-dense immune deposits in passive Heymann's nephritis. American Journal of Pathology 125(1): 1-6, 1986

Circulatory antigen of Heymann nephritis. III. Presence of the 70-kD circulatory protein in the immune deposits of Heymann nephritis. Clinical and Experimental Immunology 85(3): 469-475, 1991

Initial events in the formation of immune deposits in passive Heymann nephritis. gp330-anti-gp330 immune complexes form in epithelial coated pits and rapidly become attached to the glomerular basement membrane. Journal of Experimental Medicine 166(1): 109-128, 1987

Monocyte involvement in experimental immune complex nephritis passive heymann nephritis. Experimental Cell Biology 57(2): 98, 1989

Determinants of glomerular localization of subepithelial immune deposits effects of altered antigen to antibody ratio steroids vasoactive amine antagonists and amino nucleoside of puromycin on passive heymann nephritis in rats. Laboratory Investigation 41(1): 89-99, 1979

Localization of clusterin in the epimembranous deposits of passive Heymann nephritis. Kidney International 39(2): 247-252, 1991