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The prevalence of diabetes mellitus in sickle cell hemoglobinopathies


, : The prevalence of diabetes mellitus in sickle cell hemoglobinopathies. Journal of Clinical Endocrinology and Metabolism 48(2): 192-195

Because of the impression obtained from a population with sickle cell anemia that there were no cases of diabetics, a study was conducted to investigate the prevalence of diabetes mellitus in the following patients: 186 cases of pregnant black patients with sickle cell disease (HbS-S, S-C, or S-Thal) or HbA-S with random and 2-h postprandial blood glucose (compared to 2263 matched control patients); a study of the Hb pattern in 280 consecutive cases of nonpregnant black patients with confirmed diabetes mellitus in an outpatient clinic; and a review of the records of 711 patients with sickle cell disease in a Sickle Cell Center with performance of a 100-g oral glucose tolerance test on 5 patients with random plasma glucose greater than 120 mg/dl. There were no diabetics in pregnant black patients as compared to a 4% incidence of abnormal glucose tolerance in a control, matched population. There were no cases of sickle cell disease in the diabetic population. There was a glucose tolerance test revealing normal glucose, insulin and glucagon responses in 5 of the patients tested. An examination of the records of 711 patients with sickle cell disease for signs and symptoms of diabetes mellitus revealed no patient with such symptoms or any who was on insulin or oral hypoglycemic agents. The low prevalence rate of diabetes mellitus in the patients with sickle cell disease was demonstrated. The significance of these findings are not apparent at this time; however, the importance of these results need to be established in collaborative research efforts with other centers.

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Accession: 041720769

PMID: 429473

DOI: 10.1210/jcem-48-2-192

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