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The preventive effect of prednisolone on leukotriene D4-inducing bronchospasm

, : The preventive effect of prednisolone on leukotriene D4-inducing bronchospasm. Taiwan Yi Xue Hui Za Zhi. Journal of the Formosan Medical Association 86(10): 1036-1041

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Accession: 041721575

PMID: 3437256

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Kreutner, W.; Sherwood, J.; Rizzo, C., 1989: The effect of leukotriene antagonists, lipoxygenase inhibitors and selected standards on leukotriene-mediated allergic bronchospasm in guinea pigs. Leukotrienes (LT) C4, D4, and E4 are major contributors to the pathobiology of human bronchial asthma. Therefore, it is likely that compounds that antagonize the action or inhibit the formation of LTs will be useful therapeutic agents. We have stu...

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Bremm K.D.; Koenig W.; Pfeiffer P.; Rauschen I.; Theobald K.; Thelestam M.; Alouf J.E., 1985: Effect of thiol activated toxins streptolysin o alveolysin and theta toxin on the generation of leukotrienes and leukotriene inducing and leukotriene metabolizing enzymes from human polymorphonuclear granulocytes. The generation of leukotrienes (LTC4, LTD4, LTE4, and LTB4; 12-epi-LTB4 isomer) from human granulocytes by thiol-activated toxins (steptolysin O, alveolysin from Bacillus alvei, and theta toxin from Clostridium perfringens) is described. The relea...

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Cheng, J.B.; Townley, R.G., 1984: Effect of the serine-borate complex on the relative ability of leukotriene C4, D4 and E4 to inhibit lung and brain [3H] leukotriene D4 and [3H] leukotriene C4 binding: demonstration of the agonists' potency order for leukotriene D4 and leukotriene C4 receptors. To define the potency order of the leukotrienes for inhibition of [3H] leukotriene D4 and [3H] leukotriene C4 binding, we investigated leukotriene C4, D4 and E4 competition with and without the serine-borate complex in guinea pig lung and brain ho...

Tsunoda, H.; Katayama, S.; Sakuma, Y.; Tanaka, S.; Tsukidate, K.; Abe, S.; Yamatsu, I.; Katayama, K., 1991: Effect of a novel 5-lipoxygenase inhibitor, E6080 on bronchospasm, airway cellular infiltration and leukotriene production in guinea pigs. 6-Hydroxy-2-(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride (E6080), an orally active and selective 5-lipoxygenase inhibitor, dose-dependently inhibited the bronchospasm induced by antigen (ovalbumin) inhalation in sensitized...

Shindo, K.; Koide, K.; Fukumura, M.; Hirai, Y., 1996: In vivo effect of prednisolone on release of leukotriene B4 from neutrophils from asthmatic patients. We examined the release of leukotriene B4 from calcium ionophore A23187-stimulated neutrophils from asthmatic patients treated with or without intravenous prednisolone during an asthmatic attack. The mean level of LTB4 in the supernatant of stimul...

Austen K.F.; Corey E.J.; Drazen J.M.; Leitch A.G., 1983: The effect of indomethacin on the contractile response of the guinea pig lung parenchymal strip to leukotriene b 4 leukotriene c 4 leukotriene d 4 and leukotriene e 4. Indomethacin [a Cyclo-oxygenase inhibitor] (1 .mu.g/ml) almost totally inhibited the dose-dependent contractile response of isolated lung parenchymal strips of the guinea pig (GPLS) to leukotriene B4 (LTB4) over the concentration range 0.18-18 nM....