EurekaMag.com logo
+ Translate

The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes


, : The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes. Journal of Immunology 137(11): 3671-3674

All HLA-B locus molecules have either the Bw4 or Bw6 epitopes. In addition, the Bw4 epitope is found on HLA-Aw23, Aw24, and A32, and Bw6 is also found on HLA-Cw3. The structural basis for these determinants and the evolution of their distribution among products of the HLA-B locus has been a long standing puzzle. To identify residues that may be involved in these determinants, we have cloned a gene for A32 and sequenced the protein encoding exons. Comparison of the predicted protein sequence with other HLA-A,B,C sequences identified residues 79 through 83 of the alpha 1 domain as having a pattern of polymorphic substitution that correlates with the presence and absence of the Bw4 and Bw6 epitopes.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 041721835

PMID: 2431040

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Hughes Wiener G.; Wiener P.H., 1986: Sex differences in perception of attributes important for intercultural relationships. 128 young adults experienced in intercultural relations were asked to rate each of 121 personal attributes hypothesized to be important to successful intercultural relationships. An analysis of responses yielded the unexpected finding that men and...

Hargreave, M.; Jensen, A.; Deltour, I.; Brinton, L.A.; Andersen, K.K.; Kjaer, S.K., 2013: Increased risk for cancer among offspring of women with fertility problems. Some studies have indicated that children born after fertility treatment have a potential risk for cancer, but the results are inconsistent. Furthermore, any negative effects of fertility treatment might be due to the underlying infertility rather...

Peixoto M.A.P.; Chaves Netto H.; Montenegro C.A.B., 1990: Statistics basic concepts. Statistics deals with variation. Its main branches are descriptive and inferencial statistics. The first one describes data, making some sense of them. The conclusions of description are specific for that experimental group. Inferencial statistics...

Gelber, R.P.; Launer, L.J.; White, L.R., 2012: The Honolulu-Asia Aging Study: epidemiologic and neuropathologic research on cognitive impairment. The Honolulu-Asia Aging Study (HAAS) is a longitudinal epidemiologic investigation of rates, risk factors, and neuropathologic abnormalities associated with cognitive decline and dementia in aged Japanese-American men. The project was established...

Yuan HongXu; Xu XinPing; Zhang JianZhong; Guo JianFu; Li BaoJian, 2004: Characters of resistance to rice sheath blight of Zhongda 2, a transgenic rice line modified by chitinase gene (RC24). Zhongda 2, a transgenic line derived from the indica cultivar Zhuxian B though the modification of its rice chitinase gene (RC24), had high resistance to sheath blight (Rhizoctonia solani) in both laboratory and field conditions in Guangdong, Chin...

Boycott, RC.; Ortwin, B., 1988: The South African tortoise book. A guide to South African tortoises, terrapins and turtles. Unknown

Bezy, R. L., 1967: A new night lizard Xantusia vigilis sierrae from the southern Sierra Nevada in California. Journal of the Arizona Academy of Science, 4: 163-167

Velardi A.; Albi N.; Dembech C.; Terenzi A.; Aversa F.; Martelli M.F., 1990: Clonable cd3+ lak precursors after t depleted bone marrow transplantation. Bone Marrow Transplantation 5(SUPPL 2): 118

Chick, G. C., 1903: Note on Dr J. E. Gray's type-specimens of Jurassic Ammonites from India. Proceedings of the Malacological Society of London, V 285-289

Dahl H.; Norskov K.; Peitersen E.; Hilden J., 1984: Zinc therapy of acetazolamide induced side effects. A double-blind corss-over trial extending over 4-wk with adminstration of 0.2 g zinc sulfate 3 times daily and a placebo was carried out on 12 patients having grave acetazolamide-induced side-effects manifesting themselves as gustatory disorder, a...