+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

The problem of thalassemia in Thailand



The problem of thalassemia in Thailand



Southeast Asian Journal of Tropical Medicine and Public Health 23(Suppl. 2): 1-6



About one per cent of the Thai population are affected with thalassemic diseases. In each year there are almost 50,000 pregnancies at risk of having an affected fetus, one fourth of which result in thalassemic newborns. Both alpha- and beta -thalassemia, including hemoglobins E and Constant Spring, are common in Thailand. Their distribution varies from region to region and among different ethnic groups. About 30-40% of the population are carriers of at least one of the abnormal genes. Thalassemias and hemoglobinopathies are common and heterogeneous in Thailand. They combine to give more than 60 thalassemic syndromes with varying clinical severity. Abnormalities can be detected in every organ system. Studies in detail into each clinical problem will lead to better management. Hematological and molecular studies on different types of thalassemia in Thailand have made it possible to give prenatal diagnosis service to those pregnancies at risk of having a thalassemic child. Sporadic services have been given in three centers. Systematic prevention and control program is being planned by the cooperation of both the public and private sectors.

(PDF emailed within 1 workday: $29.90)

Accession: 041723045

Download citation: RISBibTeXText

PMID: 1298980


Related references

Molecular, hematological and clinical aspects of thalassemia major and thalassemia intermedia associated with Hb E-β-thalassemia in Northeast Thailand. Blood Cells, Molecules, and Diseases 42(1): 0-35, 2009

Molecular Understanding of Non-Transfusion-Dependent Thalassemia Associated with Hemoglobin E-β-Thalassemia in Northeast Thailand. Acta Haematologica 136(4): 233-239, 2016

Molecular analysis of common types of alpha-thalassemia associated with beta-thalassemia in Northern Thailand. Acta Medica Nagasakiensia 43(1-2): 33-37, 1998

Genotype and phenotype characterizations in a large cohort of β-thalassemia heterozygote with different forms of α-thalassemia in northeast Thailand. Blood Cells, Molecules and Diseases 47(2): 120-124, 2012

Thalassemia: pathophysiology and management. Part B. Proceedings of the International Conference on Thalassemia. Bangkok, Thailand, June 30-July 3, 1985. Birth Defects Original Article Series 23(5b): 1-485, 1988

Problems in determining thalassemia carrier status in a program for prevention and control of severe thalassemia syndromes: a lesson from Thailand. Clinical Chemistry and Laboratory Medicine 51(8): 1605-1614, 2014

Thalassemia: pathophysiology and management. Part A. Proceedings of the International Conference on Thalassemia. Bangkok, Thailand, June 30-July 3, 1985. Birth Defects Original Article Series 23(5a): 1-612, 1987

Hemoglobin Q-Thailand and its combinations with other forms of thalassemia or hemoglobinopathies in northern Thailand. Clinical Laboratory 60(7): 1099-1103, 2014

Beta-thalassemia associated with alpha-thalassemia in Thailand. Hemoglobin 12(5-6): 581-592, 1988

Molecular basis of beta-thalassemia in Thailand: analysis of beta-thalassemia mutations using the polymerase chain reaction. Human Genetics 84(1): 41-46, 1989

The associations of SEA-alpha thalassemia 1, XmnI-Ggamma polymorphism and beta-globin gene mutations with the clinical severity of beta-thalassemia syndrome in northern Thailand. Journal of the Medical Association of Thailand 97(3): 300-307, 2014

Homozygous beta thalassemia in American Blacks: the problem of mild thalassemia. Journal of Laboratory and Clinical Medicine 81(6): 857-866, 1973

Soils of the ASPAC region. 5. Thailand. (a) The description and classification of the soils of Thailand. (b) The reclamation of some problem soils in Thailand. Technical Bulletin, ASPAC Food and Fertilizer Technology Center, Taiwan (14): 49, 1973

Thalassemia in Thailand. Annals of the New York Academy of Sciences 344: 352-363, 1980

Alpha-thalassemia in Thailand. Hemoglobin 12(5-6): 485-498, 1988