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The role of adenine nucleotide translocator in the regulation of oxidative phosphorylation in heart mitochondria

Kholodenko, B.N.; Zhilinskene, V.I.; Borutaĭte, V.I.; Ivanovene, L.I.; Toleĭkis, A.I.

Biokhimiia 53(6): 1009-1012

1988

ISSN/ISBN: 0320-9725
PMID: 2846076
Accession: 041740771
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The regulatory role of adenine nucleotide translocase in oxidative phosphorylation was determined by titration of respiration of isolated rabbit heart mitochondria with carboxyatractyloside in the creatine phosphokinase ADP-regenerating system, which is not rate-limiting. It was found that the respiration rate is not controlled by adenine nucleotide translocase in states 3 and 4. Within the physiological region of respiration (30-70% of the maximal rate), the control coefficient for ADP/ATP translocase is 0.62-0.75. Thus, translocase plays a key role in the regulation of oxidative phosphorylation.

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Related References

Kholodenko, B.; Zilinskiene, V.; Borutaite, V.; Ivanoviene, L.; Toleikis, A.; Praskevicius, A. 1987: The role of adenine nucleotide translocators in regulation of oxidative phosphorylation in heart mitochondria Febs Letters 223(2): 247-250
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