+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

The role of the lateral cortico-cortical prefrontal pathway in self-stimulation of the medial prefrontal cortex in the rat



The role of the lateral cortico-cortical prefrontal pathway in self-stimulation of the medial prefrontal cortex in the rat



Behavioural Brain Research 31(3): 257-265



Effects of electrolytic and kainic acid lesions at several stereotaxic planes of the lateral cortico-cortical prefrontal efferent pathway on self-stimulation of the medial prefrontal cortex were investigated. Electrolytic bilateral lesion of the sulcal prefrontal cortex, the first terminal area of this pathway, produced no effects on self-stimulation of the medial prefrontal cortex. However, bilateral electrolytic lesion of this pathway at the rostral part of the external capsule produced a permanent abolition of self-stimulation of the medial prefrontal cortex. These effects seemed selective since operant behaviour to obtain water, similar to that performed for self-stimulation and used as a control, was not affected by the lesion except on the 1st, 3rd (P less than 0.01) and 5th (P less than 0.05) days postlesion. Interestingly, bilateral microinjections of kainic acid (10 nmol in 0.8 microliters) at the same stereotaxic planes of the external capsule where electrolytic lesion was produced, had no effects on self-stimulation. These results suggest that fibres-of-passage through the external capsule are responsible for the abolition of self-stimulation. Bilateral electrolytic lesion of the entorhinal cortex, one of the caudal terminal areas of this descending set of fibres, produced a short transient decrease of self-stimulation of the medial prefrontal cortex. These results are discussed on the basis that complex, rather than single circuits are involved in maintaining self-stimulation in this neocortical area.

(PDF emailed within 0-6 h: $19.90)

Accession: 041748856

Download citation: RISBibTeXText

PMID: 2914076

DOI: 10.1016/0166-4328(89)90007-7


Related references

Suppression of self stimulation of the medial prefrontal cortex after lesions of sulcal prefrontal cortex or cortical injections of kainic acid. Neuroscience Letters (SUPPL 18): S126, 1984

Development of brain stimulation reward in the medial prefrontal cortex facilitation by prior electrical stimulation of the sulcal prefrontal cortex. Physiology & Behavior 28(5): 869-872, 1982

Parieto prefrontal connections in the monkey topographic distribution within the prefrontal cortex of sectors connected with the lateral and medial posterior parietal cortex. Society for Neuroscience Abstracts 11(1): 323, 1985

Topographic organization of cortico cortical connections of the prefrontal component of medial precentral cortex in rats. Society for Neuroscience Abstracts 12(2): 1438, 1986

Partial overlap of amygdalo-cortical fibers and cortico-amygdalar neurons in the medial prefrontal cortex of the rat. Society for Neuroscience Abstracts 27(1): 469, 2001

Lateral Orbitofrontal Cortical Modulation on the Medial Prefrontal Cortex-Amygdala Pathway: Differential Regulation of Intra-Amygdala GABAA and GABAB Receptors. International Journal of Neuropsychopharmacology 20(7): 602-610, 2017

Activation of medial prefrontal cortex by phencyclidine is mediated via a hippocampo-prefrontal pathway. Cerebral Cortex 15(5): 663-669, 2004

Chronic deep brain stimulation of the rat ventral medial prefrontal cortex disrupts hippocampal-prefrontal coherence. Experimental Neurology 269: 1-7, 2015

Corticotropin-releasing factor infusion into nucleus incertus suppresses medial prefrontal cortical activity and hippocampo-medial prefrontal cortical long-term potentiation. European Journal of Neuroscience 38(4): 2516-2525, 2014

Ginsenoside Rg1 modulates medial prefrontal cortical firing and suppresses the hippocampo-medial prefrontal cortical long-term potentiation. Journal of Ginseng Research 42(3): 298-303, 2018

Footshock stress facilitates self-stimulation of the medial prefrontal cortex but not the lateral hypothalamus in the rat. Brain Research 490(2): 397-403, 1989

Ventral medial prefrontal cortex (vmPFC) as a target of the dorsolateral prefrontal modulation by transcranial direct current stimulation (tDCS) in drug addiction. Journal of Neural Transmission 123(10): 1179-1194, 2018

Is the prefronto entorhinal pathway involved in self stimulation of the medial prefrontal cortex of the rat. Neuroscience Letters Supplement (22): S161, 1985

Inhibitory modulation of medial prefrontal cortical activation on lateral orbitofrontal cortex-amygdala information flow. Journal of Physiology 595(17): 6065-6076, 2017

Stimulation of cortical serotonin - 2a receptors increases dopamine release in the rat medial prefrontal cortex. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 461 9, 2003