The sites of cleavage in oxidized insulin-B chain by a hemorrhagic protease derived from the venom of the habu (Trimeresurus flavoviridis)

Yamakawa, Y.; Omori-Satoh, T.

Toxicon Official Journal of the International Society on Toxinology 26(2): 227-231

1988


ISSN/ISBN: 0041-0101
PMID: 3284004
DOI: 10.1016/0041-0101(88)90178-x
Accession: 041756280

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Abstract
The substrate specificity of a hemorrhagic protease derived from habu (Trimeresurus flavoviridis) venom was determined using oxidized insulin-B chain as a substrate. The enzyme was shown to be a fairly specific protease; it cleaved the substrate essentially at two positions, His10-Leu11 and Ala14-Leu15. The sites cleaved with the protease were compared to those reported with hemorrhagic proteases from other snake venoms.