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Three-dimensional structure for the beta 2 adrenergic receptor protein based on computer modeling studies

Three-dimensional structure for the beta 2 adrenergic receptor protein based on computer modeling studies

Journal of Molecular Biology 225(3): 859-871

ISSN/ISBN: 0022-2836

PMID: 1318386

Computer-aided model building techniques have been used to construct three-dimensional model structures for hamster beta 2 adrenergic receptor. Experimental data were used as constraints to guide the model building procedure, and a number of rather strict criteria were applied to assess the physical plausibility of model structures. We present details of our best model structure to date, which is consistent with a large body of experimental data. We also discuss in detail our model building procedures and evaluation criteria, which we believe may be of general utility in modeling projects.

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Accession: 041803141

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