Section 42
Chapter 41,844

Transrepression of the N-myc expression by c-myc protein

Kubota, Y.; Kim, S.H.; Iguchi-Ariga, S.M.; Ariga, H.

Biochemical and Biophysical Research Communications 162(3): 991-997


ISSN/ISBN: 0006-291X
PMID: 2669755
DOI: 10.1016/0006-291x(89)90771-7
Accession: 041843608

In the human neuroblastoma cell line IMR32 the N-myc gene happens to be amplified and actively expressed, whereas no stable c-myc RNA can be detected in the same cells. In this report, we show that in IMR32 cells the expression of the N-myc gene is repressed by introduction of a c-myc expression vector (c-myc cDNA conjugated with an SR promoter). Moreover, dose response experiments showed that the amount of endogenous c-myc protein present in HeLa cells (which express c-myc but not N-myc) is enough to repress the expression of N-myc in IMR32 cells.

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