+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Treatment of digitalis intoxication by charcoal hemoperfusion (CHP)



Treatment of digitalis intoxication by charcoal hemoperfusion (CHP)



Transactions - American Society for Artificial Internal Organs 22: 718-722



In the present communication, we demonstrate the removal of digoxin both in vitro and in vivo from digoxin intoxicated dogs by use of hemoperfusion over activated charcoal. In vitro drug removal was 33 ml/min at mean blood flow rates of 160 ml/min. By 30 mins of in vitro perfusion 51% of drug was removed from the reservoir and by 2 1/2 hrs 83%. In vivo clearance in dogs was 55 ml/min at blood flow rates of 150 ml/min. In view of the poor success that has been encountered in the treatment of digoxin intoxication with other modalities, charcoal hemoperfusion may represent an effective method of rapid digoxin removal from blood.

(PDF emailed within 1 workday: $29.90)

Accession: 041852989

Download citation: RISBibTeXText

PMID: 951891


Related references

Hemoperfusion in digitalis intoxication: a comparative study of coated versus uncoated charcoal. Transactions - American Society for Artificial Internal Organs 23: 730-731, 1977

Treatment of patients with acute digitalis poisoning by charcoal hemoperfusion. Vutreshni Bolesti 26(5): 46-50, 1987

Charcoal hemoperfusion in the treatment of levothyroxine intoxication. Thyroid 20(2): 209-212, 2010

Charcoal hemoperfusion as treatment for Carbamazepine acute intoxication. Acta Anaesthesiologica Italica 46(2-3): 191-194, 1995

Activated charcoal hemoperfusion in the treatment of severe hypnotic intoxication. Zhonghua Yi Xue Za Zhi 63(5): 266-269, 1983

Successful treatment of acute dapsone intoxication using charcoal hemoperfusion. Australian and New Zealand Journal of Medicine 13(5): 509-512, 1983

Theophylline intoxication: clinical features and pharmacokinetics during treatment with charcoal hemoperfusion. Israel Journal of Medical Sciences 32(9): 766-770, 1996

Treatment of an infant with severe chloramphenicol intoxication using charcoal-column hemoperfusion. Journal of Pediatrics 96(1): 136-139, 1980

The treatment of severe drug intoxication with charcoal hemoperfusion in series with hemodialysis. Journal of Dialysis 3(4): 337-348, 1979

Albumin-collodion activated charcoal hemoperfusion in the treatment of severe theophylline intoxication in a 3-year-old patient. Pediatrics 65(4): 811-814, 1980

Continuous arteriovenous hemofiltration as additional treatment to charcoal hemoperfusion of fulminant hepatic failure following paracetamol intoxication. Blood Purification 2(1): 63, 1984

Charcoal hemo perfusion a possible treatment of severe digitalis intoxication. Intensivmedizin 14(2): 96-100, 1977

Hemoperfusion In Digitalis Intoxication. Asaio Journal 23(1): 730-731, 1977

Charcoal hemoperfusion for phenytoin intoxication. Indian Pediatrics 49(2): 152-153, 2012

Charcoal hemoperfusion in experimental iron intoxication. Veterinary & Human Toxicology 32(4): 349, 1990